Evidence mapPaperPMID 42094607Full record

ReviewTheranostics2026

Current trends regarding types, properties, self-healing mechanisms, and therapeutic strategies for diabetic wounds addressed with polysaccharide-based self-repairing hydrogels: a review.

Hongkun Xue, Yuxin Bian, Ruoshi Zhang, Ziye Yuan, Haipeng Liu, Chuan Wang, Jiaqi Tan

Abstract readReview
In one paragraph

Review in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hongkun XueCollege of Traditional Chinese Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding, 071000, China.
Yuxin BianSchool of Clinical Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding, 071000, China.
Ruoshi ZhangSchool of Clinical Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding, 071000, China.
Ziye YuanSchool of Clinical Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding, 071000, China.
Haipeng LiuDepartment of Neurosurgery, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Lianchi District, Baoding, 071000, China.
Chuan WangSchool of Clinical Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding, 071000, China.
Jiaqi TanCollege of Traditional Chinese Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding, 071000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the global prevalence of diabetes continues to rise, approximately 19% to 34% of diabetes patients will develop chronic wounds or ulcers, which significantly impacts the quality of life of these patients and also imposes a heavy economic burden on the global healthcare system. The traditional treatment methods (debridement, antibiotics, regular dressing changes, hyperbaric oxygen therapy, etc.) are facing numerous challenges, including the increasing problem of bacterial resistance, high treatment costs, and poor long-term efficacy. Therefore, developing efficient and safe new treatment strategies for diabetic wounds has become a current research hotspot. Polysaccharide-based self-healing hydrogels (PSHs) have become one of the most promising wound dressings due to their excellent self-healing ability, good biodegradability, biocompatibility, and multiple biological activities. Unfortunately, there are still limitations in the research on PSHs in the field of diabetes wound treatment. Firstly, this review comprehensively introduces the types of polysaccharides with therapeutic effects on diabetic wounds and their excellent properties. Subsequently, this article systematically reviews the self-healing mechanisms of PSHs and the therapeutic strategies for diabetic wounds. Finally, this paper reviews the challenges and future prospects of PSHs in the clinical transformation of diabetic wounds. The results provide an important reference for the application of PSHs in the field of diabetes wound treatment.

Indexed as

Diabetes ComplicationsDiabetes MellitusHydrogelsPolysaccharidesWound HealingWounds and InjuriesAnimalsBandagesHumansHydrogelsPolysaccharidesdiabetic woundhydrogelpolysaccharideself-healingtherapeutic strategies

Identifiers

PMID42094607
PMCPMC13142794

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.