ArticleThe World Allergy Organization journal2026
Integrated transcriptomic analysis identifies tsRNA-mRNA regulatory axis in asthma pathogenesis.
Article in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Asthma is a complex respiratory disorder with incompletely understood molecular mechanisms. tRNA-derived small RNAs (tsRNAs), a newly discovered class of non-coding RNAs, have been implicated in various diseases, but their role in asthma pathogenesis remains largely unexplored. Methods: We performed an integrated analysis of tsRNA and mRNA profiles in bronchial epithelial cells from severe asthma patients (GSE85215, GSE85214) and healthy controls. Differentially expressed tsRNAs were identified using MINTmap and DESeq2 ( Results: We identified 58 dysregulated tsRNAs and 961 differentially expressed mRNAs in asthma. A regulatory network revealed 343 negatively correlated tsRNA-mRNA pairs, with 36 hub mRNAs validated in GSE201955. Three candidate tsRNAs (tRF-18-SX73IE03, tRF-22-BZBZOS4Y1, tRF-22-MI7O3B1N4) showed consistent dysregulation in HDM-exposed cells. Mechanistically, tRF-21-Z4NY2V7KE directly suppressed MYBL1 expression, as confirmed by luciferase assays. Conclusions: Our study provides the first comprehensive tsRNA-mRNA regulatory network in asthma, uncovering novel post-transcriptional mechanisms in bronchial epithelial cells. The identified tsRNAs and their targets may be potential biomarkers; moreover, they warrant further investigation as therapeutic targets for asthma.
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