Evidence map›Paper›PMID 42095668›Full record

ArticlemSystems2026

Microbial genetic screen identifies bacterial genes that compromise

Ziling Yang, Huigui Guo, Yudong Zhang, Xinzhou Jia, Yalun Wu, Tao Zhu, Ying Li, Jinyue Wang, Dianshuang Zhou, Zuobin Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziling Yang *Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.ORCID 0009-0000-1989-3206
Huigui Guo *Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.
Yudong Zhang *School of the First Clinical Medicine, Xuzhou Medical University, Xuzhou, China.
Xinzhou JiaKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.
Yalun WuKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.
Tao ZhuKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.
Ying LiKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.
Jinyue WangKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.
Dianshuang ZhouKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.ORCID 0000-0002-9205-4641
Zuobin ZhuKey Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Xuzhou, China.ORCID 0000-0003-1022-5943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms by which microbial genetic variation governs host reproductive fitness remain to be determined. Defining the causal relationship between specific microbial genes and host reproduction not only facilitates understanding of the microbe-host interaction mechanism but also provides new insights for reproductive health interventions. However, the complexity of the gut microbial community poses a challenge, and related research has been constrained by a lack of systematic approaches. In the present study, we utilized the

Indexed as

Caenorhabditis elegansEscherichia coliGenes, BacterialGenetic FitnessAnimalsReproductionmicrobial genetic variationmulti-omicsoxidative phosphorylationreproductive fitness

Identifiers

PMID42095668
PMCPMC13289084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.