Evidence map›Paper›PMID 42096281›Full record

ArticleThe Journal of clinical investigation2026

17β-Estradiol counteracts pathological microtubule remodeling to enhance right ventricular function in preclinical models.

Ryan A Moon, Rafael Sobrano Fais, Minwoo Kim, Neal T Vogel, Jenna B Mendelson, Lynn M Hartweck, John P Carney, Melissa K Gardner, Sally E Prins, Sasha Z Prisco and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ryan A MoonLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA.
Rafael Sobrano FaisDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado, USA.
Minwoo KimLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA.
Neal T VogelLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA.
Jenna B MendelsonDepartment of Integrative Biology and Physiology.
Lynn M HartweckLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA.
John P CarneyExperimental Surgical Services, Department of Surgery; and.
Melissa K GardnerDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Sally E PrinsGazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Sasha Z PriscoLillehei Heart Institute, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota, USA.
Tim LahmDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado, USA.
Kurt W PrinsGazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

GP130 Antagonism in Porcine RV Pressure OverloadR01HL162927 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$3.3M
Multi-scale Investigation of Sex Differences in Right Ventricular Function via Estrogen-Microtubule InteractionsR01HL158795 · NHLBI · UNIVERSITY OF MINNESOTA · PI Kurt W Prins · 2022 to 2026
$2.8M
NHLBI NIH HHS R01 HL158795NHLBI NIH HHS R01 HL162927
6 · The paper itself

Abstract

Estrogen exerts cardioprotective effects via microtubule regulation.

Indexed as

EstradiolMicrotubulesVentricular Function, RightAnimalsHumansMiceEstradiolCardiologyCell biologyCytoskeleton

Identifiers

PMID42096281
PMCPMC13318100

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.