Evidence map›Paper›PMID 42096289›Full record

Observational studyJCI insight2026

Impact of older donor age in kidney transplants in a biopsy-based observational study.

Katelynn Madill-Thomsen, Martina Mackova, Jessica Chang, Enver Akalin, Tarek Alhamad, Sanjiv Anand, Miha Arnol, Rajendra Baliga, Mirosław Banasik, Christopher Blosser and 62 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01299168 (Multi-centric Observational Study to Analyse the Diagnostic Molecular Features in the Clinical Setting of Kidney Allograft Biopsies), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01299168 recruitingnot on this map

Multi-centric Observational Study to Analyse the Diagnostic Molecular Features in the Clinical Setting of Kidney Allograft Biopsies

TypeobservationalSponsorUniversity of AlbertaRan2011 to 2028Enrolled500ConditionsValidation Study of Molecular Diagnostic System, Development of Reporting System for Molecular Diagnosis, Incorporate Molecular Diagnosis Into Diagnostic Standards
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

72 authors.

Katelynn Madill-ThomsenAlberta Transplant Applied Genomics Centre, Edmonton, Alberta, Canada.
Martina MackovaAlberta Transplant Applied Genomics Centre, Edmonton, Alberta, Canada.
Jessica ChangAlberta Transplant Applied Genomics Centre, Edmonton, Alberta, Canada.
Enver AkalinMontefiore Medical Center, Bronx, New York, USA.
Tarek AlhamadWashington University at St. Louis, St. Louis, Missouri, USA.
Sanjiv AnandIntermountain Transplant Services, Murray, Utah, USA.
Miha ArnolUniversity of Ljubljana, Ljubljana, Slovenia.
Rajendra BaligaTampa General Hospital, Tampa, Florida, USA.
Mirosław BanasikMedical University of Wrocław, Wrocław. Poland.
Christopher BlosserUniversity of Washington, Seattle, Washington, USA.
Georg BöhmigMedical University of Vienna, Vienna, Austria.
Daniel BrennanJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jonathan BrombergUniversity of Maryland, Baltimore, Maryland, USA.
Klemens BuddeCharite-Medical University of Berlin, Berlin, Germany.
Andrzej ChamieniaMedical University of Gdańsk, Gdańsk, Poland.
Kevin V ChowThe Royal Melbourne Hospital, Parkville, Australia.
Michał CiszekWarsaw Medical University, Warsaw, Poland.
Declan de FreitasManchester Royal Infirmary, Manchester, United Kingdom.
Dominika Dęborska-MaterkowskaWarsaw Medical University, Warsaw, Poland.
Alicja Dębska-ŚlizieńMedical University of Gdańsk, Gdańsk, Poland.
Arjang DjamaliUniversity of Wisconsin, Madison, Wisconsin, USA.
Leszek DomańskiPomeranian Medical University, Szczecin, Poland.
Magdalena DurlikWarsaw Medical University, Warsaw, Poland.
Gunilla EineckeMedical University of Hannover, Hannover, Germany.
Farsad EskandaryMedical University of Vienna, Vienna, Austria.
Richard FaticaCleveland Clinic Foundation, Cleveland, Ohio, USA.
Iman FrancisHenry Ford Transplant Institute, Detroit, Michigan, USA.
Justyna FrycMedical University in Bialystok, Białystok, Poland.
John GillSt. Paul's Hospital, Vancouver, British Columbia, Canada.
Jagbir GillSt. Paul's Hospital, Vancouver, British Columbia, Canada.
Maciej GlydaWojewodzki Hospital, Poznan, Poland.
Sita GourishankarUniversity of Alberta, Edmonton, Alberta, Canada.
Marta GryczmanPomeranian Medical University, Szczecin, Poland.
Gaurav GuptaVirginia Commonwealth University, Richmond, Virginia, USA.
Petra HrubaInstitute for Experimental and Clinical Medicine, Prague, Czech Republic.
Peter HughesThe Royal Melbourne Hospital, Parkville, Australia.
Arksarapuk JittiratUniversity Hospital Cleveland Medical Center, Cleveland, Ohio, USA.
Zeljka JurekovicUniversity Hospital Merkur, Zagreb, Croatia.
Layla KamalVirginia Commonwealth University, Richmond, Virginia, USA.
Mahmoud KamelTampa General Hospital, Tampa, Florida, USA.
Sam KantJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nika KojcUniversity of Ljubljana, Ljubljana, Slovenia.
Joanna KonopaMedical University of Gdańsk, Gdańsk, Poland.
James LanSt. Paul's Hospital, Vancouver, British Columbia, Canada.
Roslyn MannonUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Arthur MatasUniversity on Minnesota, Minneapolis, Minnesota, USA.
Joanna MazurkiewiczPomeranian Medical University, Szczecin, Poland.
Marius MiglinasVilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Thomas MuellerUniversity Hospital Zurich, Zurich, Switzerland.
Marek MyślakPomeranian Medical University, Szczecin, Poland.
Beata NaumnikMedical University in Bialystok, Białystok, Poland.
Anita PatelHenry Ford Transplant Institute, Detroit, Michigan, USA.
Agnieszka Perkowska-PtasińskaWarsaw Medical University, Warsaw, Poland.
Michael PictonManchester Royal Infirmary, Manchester, United Kingdom.
Grzegorz PiechaSilesian Medical University, Katowice, Poland.
Emillio PoggioCleveland Clinic Foundation, Cleveland, Ohio, USA.
Silvie Rajnochova BloudickovaInstitute for Experimental and Clinical Medicine, Prague, Czech Republic.
Thomas SchachtnerUniversity Hospital Zurich, Zurich, Switzerland.
Sung ShinUniversity of Ulsan College of Medicine/Asan Medical Center, Seoul, South Korea.
Soroush ShojaiUniversity of Alberta, Edmonton, Alberta, Canada.
Majid SikosanaUniversity of Alberta, Edmonton, Alberta, Canada.
Janka SlatinskáInstitute for Experimental and Clinical Medicine, Prague, Czech Republic.
Katarzyna Smykal-JankowiakWojewodzki Hospital, Poznan, Poland.
Ashish SolankiJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zeljka Veceric HalerUniversity of Ljubljana, Ljubljana, Slovenia.
Ondrej ViklickyInstitute for Experimental and Clinical Medicine, Prague, Czech Republic.
Ksenija Vucur SimicUniversity Hospital Merkur, Zagreb, Croatia.
Matthew R WeirUniversity of Maryland, Baltimore, Maryland, USA.
Andrzej WiecekSilesian Medical University, Katowice, Poland.
Zbigniew WłodarczykUniversity Hospital no. 1, Bydgoszcz, Poland.
Ziad ZakyCleveland Clinic Foundation, Cleveland, Ohio, USA.
Philip F HalloranAlberta Transplant Applied Genomics Centre, Edmonton, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because older donor age is a major concern when considering kidneys for potential transplantation, we explored the actual effect of donor age on the features of kidneys that have been transplanted. We studied the correlations of donor age with molecular injury and rejection scores in 4,502 kidney transplant biopsies assessed by microarrays as well as function and postbiopsy survival. We used multivariable analyses to correct for the correlations of donor age with other predictive variables: recipient age, time of biopsy after transplant, and deceased versus living donors. Older donor age correlated with lower glomerular filtration rate (GFR) and increased acute and chronic injury transcripts but had no effect on rejection, which was anticorrelated with recipient age. Acute injury transcripts peaked immediately after transplant and regressed. Older donor age had little effect on acute molecular injury immediately after transplant but strongly increased molecular injury scores at later times, peaking about 1-year after transplant, indicating that older age does not increase molecular injury but increases failed repair after injury. As expected, older donor age correlated with increased chronic injury and lower GFR, evident from the earliest time after transplant, pretransplant aging. However, despite substantial age-related effects, the quantitative contribution of donor aging to molecular injury, function, and survival was very small.

Indexed as

KidneyKidney TransplantationTissue DonorsAdultAgedAge FactorsBiopsyFemaleGlomerular Filtration RateGraft RejectionGraft SurvivalHumansMaleMiddle AgedClinical ResearchNephrologyOrgan transplantation

Identifiers

PMID42096289
PMCPMC13313539

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.