Evidence map›Paper›PMID 42096741›Full record

ArticleStem cell research2026

Generation of an induced pluripotent stem cell line (NCHi026-A) from a patient with a partial deletion of exon 55 in the DMD gene.

Hui Lin, Stefan Nicolau, Kayla Stevens, Tatyana A Vetter, Sarah Atkins, Emma C Frair, Nicolas Wein, Ming-Tao Zhao, Liubov V Gushchina, Kevin M Flanigan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui LinThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA. Electronic address: Hui.Lin@nationwidechildrens.org.
Stefan NicolauThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA; Departments of Pediatrics, The Ohio State University, Columbus, OH, USA.
Kayla StevensThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA.
Tatyana A VetterThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA; Departments of Pediatrics, The Ohio State University, Columbus, OH, USA.
Sarah AtkinsThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA.
Emma C FrairThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA.
Nicolas WeinNantes Université, CHU de Nantes, INSERM, TaRGeT - Translational Research in Gene Therapy, UMR 1089, Nantes F-44200, France.
Ming-Tao ZhaoThe Center for Cardiovascular Research, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA; Departments of Pediatrics, The Ohio State University, Columbus, OH, USA.
Liubov V GushchinaThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA; Departments of Pediatrics, The Ohio State University, Columbus, OH, USA.
Kevin M FlaniganThe Center for Gene Therapy, The Ohio State University, Columbus, OH, USA; Departments of Pediatrics, The Ohio State University, Columbus, OH, USA; Departments of Neurology, The Ohio State University, Columbus, OH, USA. Electronic address: Kevin.Flanigan@nationwidechildrens.org.

Funding

(Project 3) Extracellular Vesicles in Monitoring and Treatment of DystrophinopathyP50HD117373 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Nizar Saad · 2024 to 2026
$6.0M
NICHD NIH HHS P50 HD117373
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder disease which is characterized by progressive muscle degeneration or weakness due to the loss of functional dystrophin expression. For use as a cell-based disease model, we generated an induced pluripotent stem cell (iPSC) line (NCHi026-A) from fibroblasts derived from a skin biopsy of a 13-year-old patient with a nucleotide deletion across the DMD intron 54/exon55 junction (c.8028-501_8078del). The resulting cell line NCHi026-A was free of transgenes, expressed pluripotency-associated stem cell markers, maintained the normal karyotype and could be differentiated into three germ layers in vitro.

Indexed as

DystrophinExonsInduced Pluripotent Stem CellsMuscular Dystrophy, DuchenneSequence DeletionAdolescentCell DifferentiationCell LineFibroblastsHumansMaleDMD protein, humanDystrophin

Identifiers

PMID42096741
PMCPMC13294680

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.