Evidence map›Paper›PMID 42096939›Full record

ArticleThe journal of prevention of Alzheimer's disease2026

Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.

Kitty K Lui, Xin Wang, Melanie A Dratva, Ella T Lifset, Jordan Stiver, Nadine C Heyworth, Qian Shen, Michael Thomas, Pamela N DeYoung, Atul Malhotra and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Time to pay attention to sleep for Alzheimer's disease in women.The journal of prevention of Alzheimer's disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kitty K LuiSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Xin WangDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Melanie A DratvaDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Department of Psychology, University of California, Los Angeles, CA, USA.
Ella T LifsetDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Jordan StiverDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Nadine C HeyworthDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Qian ShenDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Michael ThomasDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Pamela N DeYoungDepartment of Medicine, Pulmonary, Critical Care and Sleep Division, University of California, San Diego, La Jolla, CA, USA.
Atul MalhotraDepartment of Medicine, Pulmonary, Critical Care and Sleep Division, University of California, San Diego, La Jolla, CA, USA.
Erin E SundermannDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Sarah J BanksDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. Electronic address: sbanks@health.ucsd.edu.

Funding

The cardiovascular consequences of sleep apnea plus COPD (Overlap syndrome)R01HL166485 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$776k
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 to 2025
$761k
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$724k
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$663k
NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS R01 HL166485NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

backgroundEmerging evidence point to a bidirectional relationship between sleep disturbances and Alzheimer's disease (AD). Poor sleep may be an overlooked risk factor for older women, who are disproportionately affected by AD and report worse subjective sleep quality than men. High genetic AD risk-characterized by the polygenic hazard score (PHS), including apolipoprotein (APOE) ε4 carriership-may further compound the effects of disrupted sleep on AD, particularly for older women.

objectiveThis study examined the moderating effect of genetic AD risk on subjective sleep as it related to memory and tau burden in a sample of older women.

participantsThe sample consisted of older women (≥65 years old) from the Women Inflammation Tau Study. MEASUREMENT: Participants completed the Pittsburgh Sleep Quality Index (PSQI), Rey Auditory Learning Test, and Brief Visuospatial Memory Test-Revised. They also underwent [18]F-MK6240 positron emission tomography. Tau burden was calculated in composite regions across Braak stages. Genetic risk groups were characterized by PHS stratified at the 75th percentile. PSQI global score × PHS group interactions on memory composite scores (N = 69) and tau burden (N = 63) were examined.

resultsPSQI global score × PHS group interactions were observed on visual memory and pathological tau in Braak regions III/IV (ps<0.10). Poorer subjective sleep was associated with worse visual memory and greater limbic tau deposition only among higher genetic risk women (ps<0.04). No significant associations were observed for verbal memory or tau in Braak regions I/II or V/VI.

conclusionOlder women with elevated genetic AD risk and subjective sleep difficulties may be at greater risk for visual memory deficits and tau burden in regions affected in early AD. This suggests that sleep complaints may represent a promising AD risk factor. Improving sleep may be a potential intervention target for AD mitigation and prevention, particularly for older women.

Indexed as

Alzheimer DiseaseMemorySleep Wake Disorderstau ProteinsAgedAged, 80 and overApolipoprotein E4FemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMemory DisordersNeuropsychological TestsPositron-Emission TomographyRisk FactorsSleep QualityApolipoprotein E4tau ProteinsAlzheimer’s diseaseApoe ε4MemoryPolygenic hazard scoreSleeptau PET

Identifiers

PMID42096939
PMCPMC13156732

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.