Evidence map›Paper›PMID 42098071›Full record

ReviewBDJ open2026

Comparative effectiveness of alloplastic and biologic grafts in maxillary sinus augmentation: a systematic review.

Jonathan Varghese Thomas, Santosh Martande, Joshua Thomas Meenathathil, Bhushan Bhagat, Swathi Pv, Shambhavi Thakur, Krishna Suryawanshi, Nomita Yein

Abstract readReview
In one paragraph

Review in BDJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan Varghese ThomasDepartment of Periodontology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
Santosh MartandeDepartment of Periodontology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India. santosh.martande@dpu.edu.in.ORCID http://orcid.org/0000-0002-0772-3127
Joshua Thomas MeenathathilPrivate Practitioner, Scientific Dental Clinic, Edappally, Kochi, Kerala, India.
Bhushan BhagatDepartment of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
Swathi PvDepartment of Orthodontics and Dentofacial Orthopedics, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
Shambhavi ThakurDepartment of Periodontology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
Krishna SuryawanshiDepartment of Periodontology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
Nomita YeinDepartment of Periodontology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaxillary sinus augmentation is a well-established procedure to increase posterior maxillary bone volume for implant placement. Various graft materials are used, including autografts, allografts, xenografts, and alloplasts, but the clinical performance of alloplasts remains debated. METHODOLOGY: A systematic review was performed following PRISMA guidelines to compare histological, histomorphometric, radiographic, and clinical outcomes of sinus lift procedures using different grafts. Electronic searches were conducted in eight databases. Eligible studies were human clinical trials (RCTs, cohorts) comparing at least two graft materials and reporting new bone formation, graft resorption, implant survival, or complications. Eighteen studies met the inclusion criteria. Risk of bias was assessed using Cochrane RoB 2.0 and ROBINS I V2 tool.

resultsAlloplastic grafts demonstrated comparatively lower new bone formation than autogenous and allogeneic grafts, and were generally inferior to xenografts in terms of regenerative potential. They exhibited higher residual graft content, suggesting slower resorption when compared with biologic grafts. In contrast, xenografts and allografts showed more favorable integration. Volumetric outcomes indicated that alloplastic grafts provided better dimensional stability than autografts but were less effective than xenografts in maintaining graft volume and space. Radiographic findings further supported superior space maintenance with xenografts compared to alloplastic grafts. Implant survival rates were high across all graft types; however, biologic grafts demonstrated relatively improved success and lower marginal bone loss compared with alloplastic grafts.

conclusionAutografts demonstrated the highest effectiveness in maxillary sinus augmentation, followed by xenografts and alloplastic grafts, indicating a comparatively lower regenerative potential of alloplastic materials. Nevertheless, alloplastic grafts may still be considered a viable alternative in selected clinical scenarios, particularly where minimizing donor-site morbidity or reducing immunological and infection-related risks is a priority. High-quality, long-term randomized trials are needed to confirm these findings and optimize graft selection.

Identifiers

PMID42098071
PMCPMC13153208

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.