ArticleCommunications biology2026
Germ granule components regulate endosomal switching during the oocyte-to-embryo transition in Caenorhabditis elegans.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The egg cytoplasm undergoes large-scale remodeling after fertilization. Here, we reveal that the germ granule component, HERD-1, is involved in selective degradation of maternal plasma membrane proteins after fertilization in Caenorhabditis elegans. HERD-1 is specifically expressed in the germline and mainly localized in a subtype of germ granules, Z granules. HERD-1 loss caused maternal plasma membrane protein accumulation in ubiquitin-positive early and late endosomal assemblies in the early embryos. The proteomic analysis showed that HERD-1 loss substantially reduced the protein levels of a subset of endolysosomal regulators such as ESCRT-0 components regulating the multivesicular body pathway. Defects in maternal membrane protein degradation in herd-1-deficient embryos were suppressed with the loss of DEPS-1 or PRG-1, which are required for germ granule organization and small-RNA biogenesis. These results suggest that several germ granule components maintain appropriate endolysosomal component levels via small RNA-mediated regulation during the oocyte-to-embryo transition, promoting endosomal switching toward embryogenesis.
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