ArticleClinical endocrinology2026
Early Transient Hypothyroidism Is Associated With Long-Term Outcomes of 131I Treatment in Graves' Disease: A Retrospective Cohort Study.
Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRadioactive iodine (
methodsThis retrospective cohort study included 222 GD patients treated with
resultsBaseline analysis revealed that the ETH group had significantly higher pretreatment TRAb levels (median 19.30 vs. 14.35 IU/L, p = 0.021) and a higher prevalence of palpitations (84.7% vs. 64.4%, p = 0.004) compared to the Non-ETH group. Importantly, the ETH group had a significantly higher rate of developing permanent hypothyroidism (52.5% vs. 20.9%, p < 0.001), whereas the Non-ETH group was prone to persistent hyperthyroidism (55.8% vs. 28.8%). In multinomial logistic regression adjusted for dose intensity (mCi/g), Non-ETH status was a strong independent predictor for persistent hyperthyroidism (OR = 3.888, 95% CI: 1.435-10.535, p = 0.008) relative to permanent hypothyroidism. Furthermore, higher dose intensity (mCi/g) was universally associated with permanent hypothyroidism, while older age favored euthyroidism outcomes (OR = 1.055, p = 0.002).
conclusionEarly transient hypothyroidism following
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