ArticleJournal of translational medicine2026
Single-cell profiling uncovers a hypoxia-vascular-immune axis underlying poor immunotherapy response in acral versus cutaneous melanoma.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cancer immunoediting in the melanoma tumor microenvironment: from immune elimination to therapeutic resistance.Frontiers in immunology · 2026Review
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Abstract
backgroundAcral melanoma (AM), accounting for ~50% of melanomas in Asian populations, exhibits far poorer immunotherapy response (anti-PD-1 ORR < 20%) than cutaneous melanoma (CM, ~43.7%). While the tumor microenvironment (TME) plays a pivotal role in immunotherapy resistance, previous studies mainly focused on immune cells, neglecting stromal components like pericytes-creating a critical knowledge gap in understanding AM's therapeutic refractoriness.
methodsWe integrated multiple single-cell transcriptomic datasets from 31 acral melanoma, 13 cutaneous melanoma and 35 normal skin samples. Comprehensive bioinformatics analyses including cell type annotation, differential expression, gene functional enrichment, and cell-cell interaction analysis, were performed to delineate the tumor microenvironment differences between acral and cutaneous melanoma. Key findings were validated using spatial transcriptomics, bulk RNA-seq datasets, and functional assays including qPCR and western blot.
resultsAM had a more immunosuppressive TME, enriched in collagen-secreting RGS5
conclusionsThis study provides insights into vascular-stromal features associated with immunotherapy resistance in AM, highlighting RGS5
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