Evidence map›Paper›PMID 42098801›Full record

ArticleTrials2026

The REACT MCI study: a randomized controlled clinical trial on the effect of repeated advanced cognitive training in mild cognitive impairment.

S S Hernes, P R Nordnes, H R Hol, G Ringstad, A B Knapskog, P Emhjellen, G Løhaugen, M Emini, T H Edwin

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04792528 (Repeated Advanced Cognitive Training in Mild Cognitive Impairment), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04792528 naactive not recruitingnot on this map

Repeated Advanced Cognitive Training in Mild Cognitive Impairment (The REACT MCI Study). A Randomized, Controlled Trial.

TypeinterventionalSponsorSorlandet Hospital HFRan2021 to 2028Enrolled205ConditionsMild Cognitive ImpairmentArmsComputerized cognitive training., Generalized brain training / Active control
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S S HernesDepartment of Geriatric and Internal Medicine, Sorlandet Hospital Arendal HF, Arendal, Norway. susanne.sorensen.hernes@sshf.no.
P R NordnesDepartment of Geriatric and Internal Medicine, Sorlandet Hospital Arendal HF, Arendal, Norway.
H R HolDepartment of Geriatric and Internal Medicine, Sorlandet Hospital Arendal HF, Arendal, Norway.
G RingstadDepartment of Geriatric and Internal Medicine, Sorlandet Hospital Arendal HF, Arendal, Norway.
A B KnapskogUniversity of Oslo, Oslo, Norway.
P EmhjellenUniversity of Oslo, Oslo, Norway.
G LøhaugenDepartment of Pediatrics, Sorlandet Hospital Arendal, Arendal, Norway.
M EminiNorwegian Health Association, Oslo, Norway.
T H EdwinKG Jebsen Centre for Brain fluid research, Oslo, Norway.

Funding

Helse Sør-Øst RHF 2023085KLINBEFORSK 2019208
6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) and its course have multiple determining factors with both detrimental and compensatory processes in the brain. Computerized working memory training can improve cognitive function and individuals with MCI are potential targets. Since more than 1/3 of these individuals develop dementia within 5 years, any intervention postponing the progression will be immensely important. We aim to investigate the efficiency and cost-effectiveness of working memory training in MCI.

methodsIn this blinded randomized controlled trial, 213 participants will be allocated to three groups: (1) one 5-week period of working memory training, (2) two 5-week periods of working memory training, or (3) the active control group. The participants are followed for a period of 48 months (3, 6, 12, 24, and 48 months). Furthermore, we investigate microstructural effects of working memory training on magnetic resonance imaging and seek to identify high responders to training by assessing the association with function in the glymphatic system and genetic variations. Finally, the impact of working memory training on quality of life and relatives' stress, and whether it is a cost-effective approach in MCI, will be assessed. DISCUSSION: Effective therapy for MCI is lacking. Finding an intervention postponing the progression of MCI is of great importance for patients as well as for the global economy and health care.

trial registrationClinicalTrials.gov NCT04792528. Registered on 02.23.2021.

Indexed as

CognitionCognitive DysfunctionCognitive TrainingMemory, Short-TermAgedCost-Effectiveness AnalysisFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsQuality of LifeRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeCost-effectivenessMild cognitive impairmentProxyQuality of lifeWorking memory training

Identifiers

PMID42098801
PMCPMC13170189

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.