Evidence map›Paper›PMID 42098813›Full record

SynthesisJournal of translational medicine2026

Effects of the Mediterranean diet on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.

Hongya Du, Yi Feng, Ruixi Zhou, Yupeng Lei, Bixin Deng, Tiechao Ruan, Wenting Lu, Dezhi Mu

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongya Du *Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yi Feng *Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Ruixi ZhouDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. zhouruixi0104@163.com.
Yupeng LeiDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Bixin DengDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Tiechao RuanDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Wenting LuIntegrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Dezhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Funding

Fundamental Research Funds for the Central University SCU2023D006National Key R&D Program of China 2021YFC2701700, 2021YFC2701704National Natural Science Foundation of China 81971433, 82271749National Natural Science Foundation of China 82402022the Clinical research Special Fund of Wu Jieping Medical Foundation 320.6750.2023-24-4the Science and Technology of Sichuan Province 2021YFS0027
6 · The paper itself

Abstract

backgroundThe Mediterranean diet (MD) is rich in antioxidant components that can increase the antioxidant capacity of the body and improve the oxidative stress status. This systematic review and meta-analysis aimed to determine the ability of the MD to regulate oxidative stress status.

methodsThis study was conducted in accordance with the PRISMA guidelines. The PubMed, Embase, Cochrane Library, Web of Science, ClinicalTrials, and Chinese Clinical Trial databases were searched from their inception to November 2024. Randomized controlled trials that investigated the relationship between MD patterns and oxidative stress biomarkers were selected to assess the impact of the MD on oxidative stress markers.

resultsThe 20 studies included in the analysis encompassed 2,208 participants and examined 13 indicators. The MD increased the total blood antioxidant capacity (standardized mean difference [SMD]: 0.57, 95% confidence interval [CI]: 0.31 to 0.83; p < 0.001), decreased urine F2-isoprostanes (SMD: -0.40, 95% CI: -0.67 to -0.12; p = 0.005), and significantly decreased blood malondialdehyde levels (SMD: -0.70, 95% CI: -1.12 to -0.27; p = 0.001).

conclusionThese findings suggest that the MD can enhance the body's antioxidant capacity and improve lipid peroxidation. Therefore, an MD may be an effective method for reducing oxidative stress.

Indexed as

Diet, MediterraneanOxidative StressRandomized Controlled Trials as TopicAntioxidantsBiomarkersHumansMalondialdehydePublication BiasAntioxidantsBiomarkersMalondialdehydeAntioxidantsDietary patternMediterranean dietOxidative stress

Identifiers

PMID42098813
PMCPMC13321744

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.