Evidence map›Paper›PMID 42099010›Full record

ArticlePsychiatry and clinical neurosciences2026

Effects of electroconvulsive therapy on cerebellar-cerebral functional connectivity in patients with treatment-resistant depression and their correlations with gene expression profiles.

Leyi Zhang, Yiding Han, Dongsheng Lv, Ping Yao, Lixia Chen, Yonggui Yuan, Jingping Zhao, Wenbin Guo, Zhiguo Guo, Yangpan Ou

Abstract read
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In one paragraph

Article in Psychiatry and clinical neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leyi ZhangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yiding HanDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Dongsheng LvInner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China.
Ping YaoInner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China.
Lixia ChenInner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China.
Yonggui YuanDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, China.ORCID https://orcid.org/0000-0001-6496-3998
Jingping ZhaoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Wenbin GuoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0002-1626-2465
Zhiguo GuoInner Mongolia Autonomous Region Mental Health Center, Hohhot, Inner Mongolia Autonomous Region, China.
Yangpan OuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0009-0007-0691-8057

Funding

National Natural Science Foundation of China 82171508Natural Science Foundation of Hunan Province 2025JJ60706
6 · The paper itself

Abstract

aimsElectroconvulsive therapy (ECT) is an effective intervention for treatment-resistant depression (TRD). Although prior studies have identified cerebellar functional alterations following ECT, cerebellar-cerebral functional connectivity (FC) changes remain insufficiently explored.

methodsCerebellar seeds were defined based on prior connectivity studies, targeting cerebellar regions functionally coupled with executive, default-mode, and affective-limbic networks. Seed-based cerebellar-cerebral FC analyses were conducted using neuroimaging data from 72 patients with TRD (52 of whom completed post-ECT assessment) and 63 healthy controls (HCs). Correlation analyses assessed clinical associations, and support vector regression was applied to predict treatment response using baseline FC. Neuroimaging-transcriptomic association analyses were conducted to identify gene expression patterns correlated with post-ECT FC alterations.

resultsCompared to HCs, patients with TRD exhibited decreased cerebellar connectivity with the sensorimotor network (SMN) and the default-mode network (DMN). Following ECT, TRD patients showed significant alleviation of depressive symptoms, which was accompanied by a marked increase in cerebellar-DMN connectivity. Enhanced FCs between the left Crus II

conclusionsTRD is associated with reduced cerebellar-SMN and cerebellar-DMN connectivity. ECT may enhance cerebellar-DMN connectivity, potentially contributing to antidepressant effects.

Indexed as

CerebellumCerebral CortexConnectomeDefault Mode NetworkDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyNerve NetTranscriptomeAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedcerebellumfunctional connectivityneuroimaging–transcription association analysisthe default‐mode networktreatment‐resistant depression

Identifiers

PMID42099010
PMCPMC13447124

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.