Evidence map›Paper›PMID 42099461›Full record

ArticleiMeta2026

Chondroitin sulfate restores muscle mass via gut-muscle axis remodeling through sugar-bile acid metabolism reprogramming.

Ruiyun Wu, Tao Wen, Nan Shang, Penghao Xie, Zhenyu Wang, Hang Li, Shaobo Li, Dequan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruiyun WuInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products Ministry of Agriculture and Rural Affairs Beijing China.ORCID https://orcid.org/0000-0003-1030-4561
Tao WenJiangsu Provincial Key Lab for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-saving fertilizers Nanjing Agricultural University Nanjing China.ORCID https://orcid.org/0000-0003-0102-0487
Nan ShangCollege of Engineering China Agricultural University Beijing China.ORCID https://orcid.org/0000-0002-8620-4631
Penghao XieJiangsu Provincial Key Lab for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Wastes, Educational Ministry Engineering Center of Resource-saving fertilizers Nanjing Agricultural University Nanjing China.
Zhenyu WangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products Ministry of Agriculture and Rural Affairs Beijing China.
Hang LiKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering Jinan University Guangzhou China.
Shaobo LiInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products Ministry of Agriculture and Rural Affairs Beijing China.
Dequan ZhangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Integrated Laboratory of Processing Technology for Chinese Meat and Dish Products Ministry of Agriculture and Rural Affairs Beijing China.ORCID https://orcid.org/0000-0003-3277-6113

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoid-induced myopathy is characterized by progressive muscle atrophy and impaired regeneration, yet effective microbiota-oriented interventions for preserving muscle homeostasis remain largely unexplored. Here, we demonstrate that dietary chondroitin sulfate (DCS) restores muscle mass and function through a microbiota-dependent gut-muscle metabolic axis. DCS failed to confer protection in germ-free or antibiotic-treated mice, establishing gut microbiota as a prerequisite for its efficacy. Microbiota transplantation and mono-colonization experiments identified

Indexed as

chondroitin sulfateglucocorticoid‐induced myopathygut–muscle axisLactobacillus johnsoniimulti‐omics integrationNAD⁺ metabolism

Identifiers

PMID42099461
PMCPMC13147937

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.