SN38 PLGA nanoparticles provide sustained antitumor efficacy and ameliorate colitis severity in a murine colitis-associated cancer model.

Meng-Tzu Weng, Shin-Yun Liu, Chia-Yueh Hsiung, Meng-Chuan Wu, Tsung-Ying Lee, Been-Ren Lin, Yunching Chen, Shu-Chen Wei

Abstract read

In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meng-Tzu WengDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Shin-Yun LiuLiver Disease Prevention & Treatment Research Foundation, Taipei, Taiwan.

Chia-Yueh HsiungInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

Meng-Chuan WuLiver Disease Prevention & Treatment Research Foundation, Taipei, Taiwan.

Tsung-Ying LeeInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

Been-Ren LinDepartment of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Yunching ChenInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.

Shu-Chen WeiDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irinotecan is a cornerstone therapy for metastatic colorectal cancer (CRC); however, the poor solubility and instability of its active metabolite, SN38, limit its therapeutic efficacy. This study aimed to improve SN38 delivery using poly(lactic-

Indexed as

Colitis associated cancerColorectal cancerPoly (lactic-co-glycolic acid) (PLGA)SN38

Identifiers

PMID42099549

DOI10.1016/j.ijpx.2026.100552

PMCPMC13147811

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.