ReviewFrontiers in cardiovascular medicine2026
Role of exercise in cardiovascular health: a narrative review from prevention to therapeutic utilizations.
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Cardiovascular disease (CVD) continues to be the leading cause of morbidity and mortality globally, imposing a substantial burden on healthcare systems worldwide. Physical inactivity is a significant modifiable risk factor that contributes to the onset and progression of CVD. Current guidelines recommend regular aerobic and muscle-strengthening exercise, with even below-guideline volumes reducing mortality risk significantly. Notably, even physical activity levels below these recommendations can significantly reduce mortality risk, emphasizing the importance of any movement over a sedentary lifestyle. Exercise functions as both a preventive and therapeutic intervention, helping individuals with and without CVD, including those recovering from myocardial infarction or managing heart failure. At the molecular level, the IGF-1/PI3K/Akt signaling pathway plays a crucial role in exercise-induced cardiac protection by promoting balanced cardiac growth, enhancing contractility, and reducing fibrosis. Furthermore, increased endothelial nitric oxide synthase (eNOS) activity improves vascular function, antioxidant enzymes mitigate oxidative stress, and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1
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