Evidence map›Paper›PMID 42100161›Full record

ArticleFrontiers in chemistry2026

Na

Yulin Ren, Jianhua Yu, Xiaolin Cheng, A Douglas Kinghorn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yulin RenDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, United States.
Jianhua YuDivision of Hematology and Oncology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, CA, United States.
Xiaolin ChengDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, United States.
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, United States.

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · OHIO STATE UNIVERSITY · 2025 to 2025
$1.6M
NCI NIH HHS P01 CA125066
6 · The paper itself

Abstract

Tumor immunity arises from the coordinated action of innate and adaptive immune systems but is hindered by immune escape within the immunosuppressive tumor microenvironment (TME), for which ion channels and ion pumps have proved to be important. These proteins regulate a wide range of cellular processes to influence cancer progression and immune cell functions, of which ion channels maintain intracellular ion concentrations, cytosolic pH, and cell volume and functions and are essential for cancer development and immune regulation. Ion pumps correlate closely with ion channels and show an important effect on tumor immunity. Of these, H

Indexed as

cardiac glycosidesH+-ATPaseion channelsNa+/K+-ATPasetumor immunity

Identifiers

PMID42100161
PMCPMC13143946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.