SynthesisFrontiers in endocrinology2026
Luteinizing hormone activity in ovarian stimulation: comparative efficacy and safety of gonadotropins
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Background: Luteinizing hormone (LH) activity plays a crucial role in follicular development, endometrial decidualization, and embryo implantation. We aimed to compare the efficacy and safety of gonadotropins with LH activity Methods: We included randomized clinical trials (RCTs) assessing gonadotropins with LH activity with or without rFSH Results: We included 56 RCTs with 14,034 women. The evidence of gonadotropins with LH activity (±rFSH) when compared with rFSH alone probably results in little to no difference in live birth (RR = 1.07, 95%CI = 0.96-1.18; 17 studies, moderate certainty of evidence) and ongoing pregnancy (RR = 1.03, 95%CI = 0.95-1.12; 19 studies, moderate certainty of evidence), may result in a slight reduction in the number of oocytes retrieved (MD = -0.50, 95%CI = -0.88 to -0.12, Conclusions: The evidence of gonadotropins with LH activity (±rFSH) when compared with rFSH alone probably results in little to no difference in live birth and ongoing pregnancy. However, there is a slight reduction in the number of oocytes retrieved. Moreover, they are safer than rFSH alone because they probably do not increase OHSS. Therefore, based on our review, the benefit-risk balance favors the addition of an LH-active gonadotropin for the prevention of OHSS. More studies are needed to determine the effects in specific populations. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024572731, identifier CRD42024572731.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.