ArticleFrontiers in medicine2026
Association between pulse pressure levels and mortality in patients with septic shock: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Research on the impact of Pulse Pressure (PP) levels on Septic Shock patient prognosis is relatively limited. This study aims to analyze data from septic shock patients to investigate the prognostic effects of maintaining different PP levels during the early resuscitation phase. Methods: Data were extracted from the MIMIC-IV 3.1 database and septic shock patients meeting inclusion and exclusion criteria were collected from the Second Department of Critical Care Medicine at the Second Affiliated Hospital of Anhui Medical University. Patient information was gathered, and the average PP over the first 24 h in the ICU (PP Results: PP Conclusion: In our study, maintaining PP levels between 40 and 70 mmHg during early resuscitation was associated with significantly lower 28-day mortality in septic shock patients. Our exploratory findings suggest that hemodynamic management strategies might need to consider patient age. Future studies are needed to investigate whether targeting an upper PP limit in elderly patients or avoiding low PP in younger patients could improve outcomes.
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