ArticleFrontiers in medicine2026
Incidence and risk factors of acute kidney injury among neurocritical patients in high-altitude regions: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute kidney injury (AKI) is a frequent complication in intensive care unit (ICU) patients with acute brain injury. High-altitude hypoxia may aggravate renal vulnerability, but relevant evidence is limited. This study aims to investigate the incidence, risk factors, and outcomes of AKI among neurocritical patients at high altitude. Methods: Adult neurocritical patients admitted to the ICU of People's Hospital of Xizang Autonomous Region (3,650 m) from January 2022 to February 2024 were retrospectively analyzed. AKI was defined using the 2012 KDIGO serum creatinine criteria. Multivariable logistic regression identified independent predictors, and hemoglobin levels were modeled with linear spline regression. Propensity score matching (PSM) was performed to evaluate the impact of specific interventions. Results: Among 390 patients, 83 (21.3%) developed AKI within 7 days of ICU admission. Independent predictors included older age (OR = 1.058 [1.032-1.087], Conclusion: At high altitude, AKI is common in neurocritical patients and independently associated with adverse outcomes. Beyond traditional risk factors, altitude-related erythrocytosis significantly contribute to AKI risk, suggesting that tailored renal protection strategies are necessary in high-altitude neurocritical care.
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