Evidence map›Paper›PMID 42100283›Full record

ArticleFrontiers in medicine2026

Serum matrix metalloproteinase-7 as a diagnostic and prognostic biomarker in primary biliary cholangitis.

Jiahui Chen, Xiaoying Shang, Chong Peng, Luan Wang, Nana Zhang, Wenlong Lu, Mingjun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiahui Chen *Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Xiaoying Shang *Department of Clinical Laboratory, Qingdao Municipal Hospital, Qingdao, Shandong, China.
Chong PengDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Luan WangDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Nana ZhangDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Wenlong LuDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Mingjun LiuDepartment of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to assess the diagnostic and prognostic value of serum matrix metalloproteinase-7 (MMP-7) in patients with primary biliary cholangitis (PBC). Methods: Serum MMP-7 was measured using chemiluminescence immunoassay in 184 PBC patients and 94 healthy controls. PBC patients were stratified into cirrhotic ( Results: MMP-7 levels were significantly higher in PBC patients compared with healthy controls [5.12 (3.73-6.97) vs. 2.46 (1.93-2.84) ng/mL, Conclusion: Serum MMP-7 is elevated in PBC and correlates with disease severity, including cirrhosis and advanced fibrosis. It shows robust diagnostic performance as a standalone biomarker and demonstrates promise for monitoring treatment response, underscoring its potential clinical utility as a complementary non-invasive tool in PBC management.

Indexed as

biomarkercirrhosisliver fibrosismatrix metalloproteinase-7primary biliary cholangitis

Identifiers

PMID42100283
PMCPMC13143662

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.