Evidence map›Paper›PMID 42100653›Full record

ReviewFrontiers in cellular and infection microbiology2026

Hepatitis E virus-associated neurological injury and neurotropic cellular mechanisms.

Zixuan Guo, Yuewei Tian, Minheng Cheng, Wenjiao Yin, Yaxin Sun, Yubing Ou, Xiujuan Peng, Tianlong Liu, Ruiping She, Yanxin Hu and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zixuan Guo *Laboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yuewei Tian *Laboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Minheng ChengDevelopment Center of Science and Technology, Beijing Municipal Bureau of Agriculture and Rural Affairs, Beijing, China.
Wenjiao YinNational Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, NHC Key Laboratory of Medical Virology and Viral Diseases, Beijing, China.
Yaxin SunLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yubing OuLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xiujuan PengLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Tianlong LiuLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Ruiping SheLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yanxin HuLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jijing TianLaboratory of Animal Pathology and Public Health, State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) is increasingly recognized as a cause of neurological disease beyond its hepatic manifestations. Neurological complications are the most frequently reported extrahepatic presentations and include both peripheral nervous system disorders, such as Guillain-Barré syndrome (GBS) and neuralgic amyotrophy (NA), and central nervous system (CNS) involvement, including encephalitis and myelitis, often in the absence of overt hepatitis. This review summarizes the clinical spectrum of HEV-associated neurological disease and integrates evidence from human studies and experimental models. Current evidence supports multifactorial pathogenesis, with direct viral neuroinvasion of the CNS and immune-mediated mechanisms predominating in peripheral neuropathies. Experimental

Indexed as

Hepatitis EHepatitis E virusNervous System DiseasesAnimalsBlood-Brain BarrierGuillain-Barre SyndromeHumansPeripheral Nervous System Diseasescentral nervous systemhepatitis E virusimmune-mediated injuryneurological manifestationsperipheral neuropathy

Identifiers

PMID42100653
PMCPMC13143879

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.