ArticleFrontiers in microbiology2026
Acute high-intensity exercise alters gut microbiota composition and energy metabolism in different strains of mice.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The gut microbiota is a critical modulator of host energy metabolism and immune regulation. Although exercise modulates microbial composition, the temporal dynamics and strain-specific impact of acute high-intensity exercise remains unclear. Methods: This study investigated dynamic alterations in gut microbiota following acute high-intensity exercise in BALB/c and C57BL/6 mice, focusing on energy and gut health-related genera. Age-matched male mice underwent a 30-min high-intensity treadmill run. To capture temporal dynamics, colonic content samples were collected at 0, 30, and 60 min post-exercise for 16S rRNA gene sequencing. Results: Exercise induced significant remodeling of gut microbiota composition in both strains, with a notable post-exercise elevation in the Discussion: These findings provide a foundation for identifying genetic loci influencing exercise microbiota interactions, thereby providing a theoretical basis for microbiota-based personalized exercise interventions.
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