ArticleNanomedicine (London, England)2026
Microglia encapsulation in nanozyme-loaded hydrogels: response to oxidative stress and inflammation.
Article in Nanomedicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
aimTo investigate the role of hydrogel composition and nanozymes incorporation on the inflammatory response of encapsulated murine microglia.
methodsSodium alginate (SA) hydrogels containing i) hyaluronic acid (HA) of low-100 kDa or high-1 MDa molecular weight and ii) Mn
resultsHA enhanced cell-biomaterial interactions and reduced cell aggregation. Under normal culture conditions, HA induced a pro-inflammatory response, particularly with high-MW HA, with a 7-fold increase in IL-6 expression and a 2.2-fold increase in TNF-α secretion. Under prolonged LPS stimulation, HA promoted an anti-inflammatory shift, with a 2-fold decrease in IL-1β expression and restored IL-4 expression to basal levels. Mn
conclusionSA hydrogels are promising carriers for antioxidant nanozymes and microglia, modulating cell response under prolonged inflammation while protecting cells from oxidative stress.
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