Evidence map›Paper›PMID 42101108›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Intestinal Source Control of Lipid Metabolism by Enzyme-Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine-Adhesive Hydrogel Microspheres.

Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaolin WuDepartment of General Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, P. R. China.
Weiwen LiangDepartment of General Surgery (Thyroid Surgery), Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. China.
Siqi HeDepartment of Colorectal Surgery, Foresea Life Insurance Guangzhou General Hospital, Guangzhou, P. R. China.
Guangyuan ChenColorectal Surgery Unit III, Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Hui ZhouPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, P. R. China.
Xinglong WangPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, P. R. China.
Yifei LiColorectal Surgery Unit III, Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Dingcai WuPCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0003-1396-0097
Bingna ZhengThe Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Ruoxu DouDepartment of Colorectal Surgery, Foresea Life Insurance Guangzhou General Hospital, Guangzhou, P. R. China.
Rongkang HuangColorectal Surgery Unit III, Guangdong Institute of Gastroenterology, Biomedical Innovation Center, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0002-9499-0222

Funding

Guangdong Basic Research Center of Excellence for Functional Molecular EngineeringGuangdong Major Project of Basic and Applied Basic Research 2023B0303000025National Key Research and Development Program of China 2022YFA1304000National Natural Science Foundation of China 22271320National Natural Science Foundation of China 52372057Science and Technology Planning Project of Guangdong Province 2021B1212040017Shenzhen Science and Technology Program KJZD20240903101404007,JCYJ20240813150654069
6 · The paper itself

Abstract

Probiotic therapy that targets fat absorption in the small intestine holds considerable potential for regulating lipid metabolism, yet it faces challenges related to spatiotemporal delivery and colonization efficiency. To address these issues, an enzyme-probiotic biohybrid (AKK-COD) has been developed and subsequently encapsulated in thiol-modified alginate hydrogel microspheres. This therapeutic system enables sequential functions: intragastric protection, small intestinal adhesion, and probiotic release and colonization. The Ca

Indexed as

HydrogelsIntestinal MucosaIntestine, SmallLipid MetabolismProbioticsAlginatesAnimalsMiceMicrospheresAlginatesHydrogelsakkermansia muciniphilacholesterol oxidasehydrogel microsphereslipid metabolismsmall intestinal mucosa adhesion

Identifiers

PMID42101108
PMCPMC13335443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.