ArticleEuropean archives of psychiatry and clinical neuroscience2026
Ultrastructural disturbances of pericapillary microglia, perioligodendrocyte microglia, oligodendrocytes and their interactions in postmortem caudate nucleus in schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesPreviously we reported ultrastructural abnormalities of capillaries, microglia and oligodendrocytes in the prefrontal cortex in schizophrenia. We aimed to estimate the ultrastructural changes of pericapillary microglia (PCapMg), perioligodendrocyte microglia (POlMg) and oligodendrocytes adjacent to microglia in the head of the caudate nucleus (CN) in schizophrenia.
methodElectron microscopy and morphometry of microglia and oligodendrocytes in the head of the CN were performed in 21 schizophrenia cases and 20 normal controls.
resultsWe found age-related lower volume fraction (Vv) and the number (N) of mitochondria in PCapMg, POlMg and in oligodendrocytes and higher Vv and N of lipofuscin in PCapMg in the schizophrenia group as compared to the control group. Area of lipofuscin granules in PCapMg positively correlated with Vv and N of lipofuscin granules in POlMg in the schizophrenia group but not in the control group. Vv and N of mitochondria in PCapMg positively correlated with Vv of mitochondria in POlMg, and Vv and N of mitochondria in oligodendrocytes positively correlated with Vv of mitochondria in POlMg in the control group but not in the schizophrenia group.
conclusionsThese data suggest that disturbed interactions between PCapMg, POlMg and oligodendrocytes in schizophrenia are associated with altered energy and lipid metabolism, mitochondria deficit and accelerated aging of PCapMg in schizophrenia. These changes might contribute to a disturbance of blood-brain barrier in the head of the CN in schizophrenia.
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