Evidence map›Paper›PMID 42101789›Full record

ArticleJapanese journal of ophthalmology2026

Optic nerve head abnormalities in primary open-angle glaucoma and their associations with axial length.

Hitomi Saito, Weiwei Wang, Kaho Akiyama, Shuichiro Aoki, Shiroaki Shirato, Rei Sakata, Makoto Aihara, Megumi Honjo

Abstract read
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Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hitomi SaitoDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. hitomi8678@gmail.com.ORCID http://orcid.org/0000-0002-8587-6081
Weiwei WangDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Kaho AkiyamaDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Shuichiro AokiDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Shiroaki ShiratoYotsuya Shirato Eye Clinic, 2-6 Samoncho, Shinjuku-ku, Tokyo, Japan.
Rei SakataDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Makoto AiharaDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Megumi HonjoDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the frequency of peripapillary retinoschisis (PRS), lamina cribrosa defect (LCD), peripapillary intrachoroidal cavitation (PICC), and prelaminar schisis (PLS) in primary open-angle glaucoma (POAG) eyes and investigate their association with axial length (AXL). STUDY

designRetrospective cross-sectional

methodsOptical coherence tomography scans of 263 POAG eyes were reviewed for PRS, LCD, PICC, and PLS. The frequency of each optic nerve head (ONH) abnormality was compared between eyes with and without high myopia (HM), defined as AXL > 26 mm. Associations with AXL were assessed using univariable and multivariable logistic regression, adjusting for gender, age, intraocular pressure, visual field mean deviation, circumpapillary retinal nerve fiber layer thickness and Bruch's membrane opening (BMO) area.

resultsPRS, LCD, PICC, and PLS were observed in 11.8%, 31.6%, 18.3%, and 55.1% of all POAG eyes, respectively. 77.2% exhibited at least one abnormality, and 31.2% had multiple abnormalities. PRS, LCD, and PICC were more frequent in HM eyes (p = 0.001, 0.016 and <0.001, respectively) and associated with longer AXL in univariable analysis (p < 0.001). Multivariable analysis showed that PRS significantly associated with longer AXL (p < 0.001) and that LCD and PICC significantly associated with larger BMO area (p = 0.009, < 0.001). PLS was more frequent in eyes without HM (p = 0.026) and significantly associated with shorter AXL (p = 0.005).

conclusionONH abnormality was common in myopic POAG eyes with substantial overlaps. PRS, LCD and PICC were associated with longer AXL and myopic ONH structural change while PLS was associated with shorter AXL. These findings will be a foundation for further studies exploring their functional relevance.

Indexed as

Axial Length, EyeGlaucoma, Open-AngleIntraocular PressureOptic DiskOptic Nerve DiseasesTomography, Optical CoherenceAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNerve FibersRetinal Ganglion CellsRetrospective StudiesVisual FieldsLamina cribrosa defectMyopiaPeripapillary intrachoroidal cavitationPeripapillary retinoschisisPrelaminar schisis

Identifiers

PMID42101789

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.