Evidence map›Paper›PMID 42102152›Full record

ArticleBrain and behavior2026

FGF23 and Immune Cell Signatures Causally Linked to Subarachnoid Hemorrhage: Evidence From Multi-Omics and Genetic Colocalization.

Xingjie Shi, Cheng Zhang, Tao Yang, Zhiming Sun, Chao Wang, Lucheng Zhou, Shiqiang Hou, Ning Lin, Lanlan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xingjie ShiDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Cheng ZhangDepartment of Disinfection Supply Center, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Tao YangDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Zhiming SunDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Chao WangDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Lucheng ZhouDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Shiqiang HouDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.
Ning LinDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.ORCID https://orcid.org/0000-0003-0440-4304
Lanlan ZhangDepartment of Science and Education Section, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, China.

Funding

Chuzhou Science and Technology Program 2024YF007Scientific Research Foundation of the Education Department of Anhui Province 2024AH040093Scientific Research Project of the Health Commission of Chuzhou CZWJ2024A001
6 · The paper itself

Abstract

backgroundInflammation and immune response significantly contribute to brain injury following subarachnoid hemorrhage (SAH), a severe neurological condition. This study employed Mendelian randomization, colocalization, and multi-omics analysis to examine potential causal connections between inflammatory proteins, immune cells, and SAH, aiming to elucidate its pathogenesis.

methodsThis study utilized publicly available data from genome-wide association studies (GWAS), including protein QTL (pQTL) and RNA sequencing data. Bidirectional two-sample Mendelian Randomization (MR) analysis was initially employed to evaluate the cause-and-effect relationships among inflammatory proteins, immune cells, and SAH. A comprehensive multi-omics approach, encompassing transcriptome, colocalization, mediation MR, was employed to identify specific inflammatory proteins, immune cells, and potential drug targets.

resultsA causal relationship between five inflammatory proteins and SAH was identified through MR analysis (CD6, FGF23, TGFB-1, LIFR, and TGF-α). Moreover, a causal relationship with SAH was identified in 22 types of immune cells. Subsequent multi-omics analysis showed that FGF23 was a hub inflammatory protein, and its expression level was closely linked to the amount of CD4 Treg cells. Meta-analysis and replication studies identified FGF23 as a risk factor for SAH, with a colocalization score of 0.74.

conclusionThis study successfully identified inflammatory proteins and immune cells associated with SAH, and revealed the complex genetic causality and drug targets of SAH.

Indexed as

Fibroblast Growth FactorsSubarachnoid HemorrhageFibroblast Growth Factor-23Genome-Wide Association StudyHumansInflammationMendelian Randomization AnalysisMultiomicsQuantitative Trait LociFibroblast Growth Factor-23Fibroblast Growth Factorscolocalization analysisinflammatory proteinsMendelian randomizationsubarachnoid hemorrhage

Identifiers

PMID42102152
PMCPMC13155464

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.