Evidence map›Paper›PMID 42102198›Full record

ArticleScience advances2026

The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis.

Jannik Ruwisch, Aurélie Cazes, Lena M Leiber, Raphaël Borie, Lavinia Neubert, Leonard Christian, Vincent Thomas de Montpréville, Adam Szmul, Farah Moussa, Stijn E Verleden and 37 more

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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Jannik RuwischClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-1654-6668
Aurélie CazesDépartement de Pathologie, Hôpital Bichat-Claude Bernard, AP-HP and Université Paris Cité, INSERM U1149, CRI, Paris, France.ORCID 0000-0002-7172-9101
Lena M LeiberClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0009-0008-4897-1064
Raphaël BorieService de Pneumologie, Allergologie et Transplantation, AP-HP, Hôpital Bichat, F-75018 Paris, France.ORCID 0000-0002-9906-0024
Lavinia NeubertBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Leonard ChristianClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0009-0007-5779-4218
Vincent Thomas de MontprévilleInstitute of Pathology, Marie Lannelongue Hospital, Le Plessis-Robinson, France.ORCID 0000-0001-7490-4000
Adam SzmulSatsuma Lab, Hawkes Institute, University College London, London, UK.
Farah MoussaUMR 6030-ISTCT-CNRS, Normandy University, Caen, France.ORCID 0009-0005-0431-6736
Stijn E VerledenDepartment of Antwerp Surgical Training, Anatomy and Research Centre, Faculty of Medicine, University of Antwerp, Wilrijk, Belgium.ORCID 0000-0002-9656-5844
Svenja GaedckeClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-7336-7354
Jan HegermannBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.ORCID 0000-0001-7893-8507
Jan FugeClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-2926-3608
Matthias BallmaierCentral Research Facility Cell Sorting, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-1352-5995
Jan C KampClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-5002-409X
Mark GreerClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-3234-306X
Peter BraubachBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.ORCID 0000-0003-3673-7779
Christopher WerleinBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.ORCID 0000-0002-7694-4257
Fabius IusDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Theresa GraalmannBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.ORCID 0000-0003-1856-0981
Kalil AburahmaDepartment of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.ORCID 0009-0006-5507-2003
Laurens J De SadeleerDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1237-7369
Ryoko EgashiraSatsuma Lab, Hawkes Institute, University College London, London, UK.ORCID 0000-0001-7566-546X
Maximilian AckermannInstitute of Pathology, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-9996-2477
Daisuke YamadaSatsuma Lab, Hawkes Institute, University College London, London, UK.ORCID 0000-0003-1561-5908
Marius M HoeperClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-9086-2293
Christine FalkBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.ORCID 0000-0003-1376-7318
Jens GottliebClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.
Herbert B SchillerInstitute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL), Munich, Germany.
Bart VanaudenaerdeDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-6435-6901
Benjamin SeeligerClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-7373-752X
Marie-Pierre DebrayService de Radiologie, Hôpital Bichat, APHP; UMR Inserm 1149, CRI; FHU INFIRE, Paris, France.ORCID 0000-0003-2109-5662
Jean Francois BernaudinFaculty of Medicine, Sorbonne Université, Paris, France.
Lars KnudsenBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.ORCID 0000-0002-7926-3879
Emmanuel BergotDepartment of Pulmonary Medicine, Regional ILD Expert Center, University Hospital of Caen, Caen, France.
Joseph JacobSatsuma Lab, Hawkes Institute, University College London, London, UK.ORCID 0000-0002-8054-2293
Hervé MalService de Pneumologie B et Transplantation, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France.
Danny JonigkInstitute of Pathology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-5251-2281
Sabine DettmerBiomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.
Pierre MordantAssistance Publique-Hôpitaux de Paris, Service de Chirurgie Thoracique, Hôpital Bichat; INSERM, Unité 1152; Université Paris Diderot, Paris, France.
Antje PrasseClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7336-7458
Elie FadelDepartment of Thoracic Surgery and Heart-Lung transplantation, Université Paris-Saclay, Marie Lannelongue Hospital, Le Plessis Robinson, France.ORCID 0000-0002-9290-4589
Wim A WuytsDepartment of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9648-3497
Bruno CrestaniService de Pneumologie, Allergologie et Transplantation, AP-HP, Hôpital Bichat, F-75018 Paris, France.ORCID 0000-0002-2961-3455
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5917-4601
Aurélien JustetUMR 6030-ISTCT-CNRS, Normandy University, Caen, France.ORCID 0000-0002-8639-8667
Jonas C SchuppClinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7714-8076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleuroparenchymal fibroelastosis (PPFE) is a progressive interstitial lung disease (ILD) with defining histology of intra-alveolar fibrosis with septal elastosis (AFE), suggesting unique cellular disease processes. Here, we present a binational single-nucleus RNA sequencing atlas of PPFE, based on explanted lungs from 40 patients. Immunofluorescence microscopy, RNA in situ hybridization, micro-computed tomography (CT), and hierarchical phase-contrast (HiP) synchrotron CT provided spatial context. We identify PPFE-associated adventitial and elastofibrotic fibroblasts as key drivers of elastotic remodeling within an inflammatory microenvironment, maintained by immune cells forming tertiary lymphoid structures. Spatial mapping reveals an intriguing zonation of AFE, maintained by intercellular circuits between PPFE-associated cell types. Comparative analysis with idiopathic pulmonary fibrosis highlights

Indexed as

Lung Diseases, InterstitialPulmonary FibrosisFibroblastsHumansIdiopathic Pulmonary FibrosisLungX-Ray Microtomography

Identifiers

PMID42102198
PMCPMC13162212

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.