Evidence map›Paper›PMID 42102213›Full record

ArticleScience advances2026

PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.

Neus Martínez-Bosch, Noemí Manero-Rupérez, Núria Vázquez-Bellón, Bennett Nickell-Hernández, Cristina Ventura-Blanch, Nura Lutfi, Carmen G Lechuga, Carlos Martínez, Mireia Moreno, Coral Ampurdanés and 9 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Neus Martínez-BoschCancer Research Program, Hospital del Mar Research Institute (HMRI), Unidad Asociada IIBB-CSIC, Barcelona, Spain.ORCID 0000-0003-3596-0039
Noemí Manero-RupérezCancer Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, Spain.
Núria Vázquez-BellónInstitute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain.ORCID 0000-0002-0255-2875
Bennett Nickell-HernándezCancer Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, Spain.ORCID 0009-0006-5490-0970
Cristina Ventura-BlanchInstitute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain.ORCID 0009-0004-3441-3097
Nura LutfiCancer Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, Spain.ORCID 0000-0002-3761-8811
Carmen G LechugaExperimental Oncology, Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.ORCID 0000-0001-8545-552X
Carlos MartínezExperimental Pathology Unit, IMIB-LAIB-Arrixaca, Murcia, Spain.ORCID 0000-0003-3307-1326
Mireia MorenoCancer Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, Spain.ORCID 0000-0001-9575-5112
Coral AmpurdanésCancer Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, Spain.ORCID 0000-0001-8607-5561
Etna AbadDepartment of Medicine and Life Sciences, Universidad Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-9431-5817
Mar IglesiasCancer Research Program, Hospital del Mar Research Institute (HMRI), Barcelona, Spain.ORCID 0000-0002-2274-4671
María Muñoz-EscribanoCancer Research Program, Hospital del Mar Research Institute (HMRI), Unidad Asociada IIBB-CSIC, Barcelona, Spain.ORCID 0009-0001-2668-9411
Ana JanicDepartment of Medicine and Life Sciences, Universidad Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-4200-2560
Meritxell RoviraDepartment of Physiological Science, School of Medicine, L'Hospitalet de Llobregat, University of Barcelona (UB), Barcelona, Spain.ORCID 0000-0002-0538-4846
Carmen GuerraExperimental Oncology, Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
Gabriel A RabinovichLaboratorio de Glicomedicina e Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad de Buenos Aires, Argentina.ORCID 0000-0002-0947-8735
José YélamosCancer Research Program, Hospital del Mar Research Institute (HMRI), Unidad Asociada IIBB-CSIC, Barcelona, Spain.ORCID 0000-0003-1195-1496
Pilar NavarroCancer Research Program, Hospital del Mar Research Institute (HMRI), Unidad Asociada IIBB-CSIC, Barcelona, Spain.ORCID 0000-0003-4314-4584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer represents one of the most lethal tumors, characterized by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confer resistance to immunotherapy. Here, we demonstrate that deletion of poly(ADP-ribose) polymerase 2 (PARP2) in a

Indexed as

Carcinoma, Pancreatic DuctalGenomic InstabilityPancreatic NeoplasmsPoly(ADP-ribose) PolymerasesAnimalsCell Line, TumorDisease Models, AnimalDisease ProgressionHumansKiller Cells, NaturalMiceMice, KnockoutT-Lymphocytes, CytotoxicTumor MicroenvironmentParp2 protein, mousePoly(ADP-ribose) Polymerases

Identifiers

PMID42102213
PMCPMC13155354

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.