Evidence map›Paper›PMID 42102578›Full record

ArticleNeurobiology of aging2026

The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease.

Gina Faraci, Benjamin Goodfriend, Joseph Bishop, Michael Vu, Julio Avelar-Barragan, Sage J B Dunham, Jason A Rothman, Katrine L Whiteson, Amrita K Cheema, Giedre Milinkeviciute and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gina FaraciDepartment of Neurology, University of California, Irvine, CA 92617, USA; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA. Electronic address: gfaraci@uci.edu.
Benjamin GoodfriendDepartment of Neurology, University of California, Irvine, CA 92617, USA.
Joseph BishopDepartment of Neurology, University of California, Irvine, CA 92617, USA.
Michael VuDepartment of Neurology, University of California, Irvine, CA 92617, USA.
Julio Avelar-BarraganDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Sage J B DunhamDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Jason A RothmanDepartment of Microbiology and Plant Pathology, University of California, Riverside, CA 92521, USA.
Katrine L WhitesonDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Amrita K CheemaDepartment of Oncology, Georgetown University, Washington, DC 20007, USA.
Giedre MilinkeviciuteInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.
Andrea J TennerDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA; Department of Pathology and Laboratory Medicine, University of California, Irvine, CA 92617, USA.
Frank M LaFerlaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Grant R MacGregorTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
Kim N GreenInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Mark MapstoneDepartment of Neurology, University of California, Irvine, CA 92617, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA. Electronic address: mark.mapstone@uci.edu.

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

The human Triggering Receptor Expressed on Myeloid cells 2 (TREM2) gene is expressed predominantly by microglia in the brain and the R47H coding variant of TREM2 is associated with increased risk for late-onset Alzheimer's disease (LOAD). We performed lipidomic and metabolomic analysis of liver, plasma, and brain in 4- and 12-month-old Trem2

Indexed as

Alzheimer DiseaseBrainGenetic Association StudiesGenetic VariationHomeostasisLiverMembrane GlycoproteinsReceptors, ImmunologicAnimalsDisease Models, AnimalFemaleHumansLipid MetabolismMaleMice, TransgenicTriglyceridesMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mouseTriglyceridesAlzheimer’s diseaseBrainLipidLiverMetabolomicsMousePlasma

Identifiers

PMID42102578
PMCPMC13249471

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.