Evidence map›Paper›PMID 42102759›Full record

ArticlePoultry science2026

A ∼18 kb upstream deletion of H2AFY is associated with the feathered leg trait in Yanying chickens.

Kangling Li, Han Yi, Yang Xi, Jingjing Qi, Qiang Wang, Jie Yu, Yuan Bai, Lili Bai, Anqi Huang, Hehe Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kangling LiKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China.
Han YiKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China.
Yang XiFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China; College of Life Science, Sichuan Agricultural University, PR China.
Jingjing QiKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China.
Qiang WangAcademy of Agricultural Sciences·Liang Shan, Liangshan, China.
Jie YuKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China.
Yuan BaiKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China.
Lili BaiKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China.
Anqi HuangFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China; College of Life Science, Sichuan Agricultural University, PR China.
Hehe LiuKey Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology (Institute of Animal Genetics and Breeding), Sichuan Agricultural University, PR China; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, PR China; College of Life Science, Sichuan Agricultural University, PR China. Electronic address: liuee1985@sicau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feather-related traits in poultry give rise to a vibrant array of visually striking characteristics. Among these, the Yanying chickens, an indigenous breed, displays a variably expressed feathered-leg phenotype. However, the underlying genetic mechanisms remain largely unexplored, making this breed a valuable model for investigation. In present study, we performed Genome-wide association studies (GWAS) based on whole-genome resequencing data (average depth: 10 ×) of 123 chickens, and found a locus on chromosome 13 (chr13: 14.97-15.05 Mb) that is significantly associated with leg feather trait. By gene annotation, we found a coding gene for H2A-histone-family, member-Y (H2AFY), which encodes a histone variant crucial for chromatin architecture and the regulation of developmental genes, was located in this region. We then identified an approximately 18-kb deletion up-stream of H2AFY. Through PCR validation, we confirmed that this structural variation is significantly associated with the feathered-leg trait. The segregation pattern suggests it is a major genetic determinant, though with incomplete penetrance. This study not only deepens our understanding of the genetic mechanisms underlying feather-related traits but also provides a reliable genetic marker, offering a potential target for molecular-assisted selection of external characteristics in chickens.

Indexed as

Avian ProteinsChickensFeathersHistonesSequence DeletionAnimalsGenome-Wide Association StudyPhenotypeAvian ProteinsHistonesCandidate geneChickenFeathered legMolecular markersWhole genome resequencing

Identifiers

PMID42102759
PMCPMC13185909

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.