Evidence map›Paper›PMID 42103757›Full record

ReviewNPJ Parkinson's disease2026

The biological clock in parkinson's disease: mechanisms and chronotherapy.

Hong Liu, Hao Ling, Kangchao Sun, Kun Yang, Wenzhen Du, Yuxiu Ma, Yaru Wang, Kai Wang, Ying Liu, Long Niu

Abstract readReview
In one paragraph

Review in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hong Liu *Department of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Hao Ling *Department of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Kangchao SunDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Kun YangDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Wenzhen DuDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Yuxiu MaDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Yaru WangDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Kai WangDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Ying LiuInternational Medical Center, Tianjin First Central Hospital, Tianjin, China.
Long NiuDepartment of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China. longniu94@163.com.

Funding

Tianjin Science and Technology projects 21JCYBJC00880
6 · The paper itself

Abstract

Circadian disruption is increasingly recognized as a significant contributor to Parkinson's disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy's potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.

Identifiers

PMID42103757
PMCPMC13376631

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.