Evidence map›Paper›PMID 42104318›Full record

Trial reportBMC women's health2026

Effects of short-term resistance training plus whole-body neuromuscular electrical stimulation on blood cardiometabolic biomarkers in sedentary middle-aged women: a parallel-group, randomized trial.

Paulo Vitor Suto Aizava, Vitor de Salles Painelli, Leonardo de Paula Silva, Enzo Berbery Orlandi, Audrei Pavanello, Alexandre Marin Hernandez Cosialls, Kléber Elói Gomes Barbão, Pablo Valdés-Badilla, Braulio Henrique Magnani Branco

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paulo Vitor Suto AizavaInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil.
Vitor de Salles PainelliInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil. vitor.painelli@unicesumar.edu.br.
Leonardo de Paula SilvaInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil.
Enzo Berbery OrlandiInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil.
Audrei PavanelloInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil.
Alexandre Marin Hernandez CosiallsSão Camilo University Center, São Paulo, São Paulo, Brazil.
Kléber Elói Gomes BarbãoInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil.
Pablo Valdés-BadillaDepartment of Physical Activity Sciences, Faculty of Education Sciences, Universidad Católica del Maule, Talca, Chile.
Braulio Henrique Magnani BrancoInterdisciplinary Laboratory of Health Promotion Intervention, Cesumar Institute of Science, Technology and Innovation, Maringá, Paraná, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMiddle-aged women are disproportionately affected by cardiometabolic deterioration during the menopausal transition. Resistance training (RT) is an established countermeasure, and whole-body neuromuscular electrical stimulation (WB-NMES) may enhance its physiological effects. However, whether short-term RT combined with WB-NMES further improves blood cardiometabolic biomarkers in this population remains unknown.

methodsIn this parallel-group, randomized trial, 23 sedentary middle-aged women (47 ± 6 y, 86.3 ± 15.7 kg, 1.61 ± 0.06 m, 33.2 ± 6.0 kg∙m

resultsNo significant Group × Time interaction was identified for any blood biomarker. A significant main effect of Time was observed for LDL-c (P = 0.002) and total cholesterol (P = 0.001), with post-hoc analyses revealing significant within-group reductions exclusively in the RT + WB-NMES group (LDL-c: P = 0.041, ES = - 1.13; total cholesterol: P = 0.026, ES = - 0.91). No significant Group × Time interaction was found for any anthropometric, body composition, or most physical fitness variables. Lumbar traction strength improved significantly within the RT + WB-NMES group (P = 0.029, ES = 0.99) but not in RT alone (P = 0.569, ES = 0.53).

conclusionsSix weeks of RT combined with WB-NMES accelerated reductions in LDL-c and total cholesterol in sedentary middle-aged women, although statistical superiority over RT alone was not demonstrated. These preliminary findings support the cardiometabolic relevance of short-term RT + WB-NMES, though larger trials are required.

trial registrationU111113186998 https://ensaiosclinicos.gov.br/rg/RBR6zx5zcz . Registered on 10/09/2025.

Indexed as

BiomarkersElectric Stimulation TherapyResistance TrainingSedentary BehaviorBlood GlucoseBody CompositionCholesterolC-Reactive ProteinFemaleHumansMiddle AgedPhysical FitnessTriglyceridesBiomarkersBlood GlucoseCholesterolC-Reactive ProteinTriglyceridesBody compositionElectrical stimulationMiddle-agedResistance training

Identifiers

PMID42104318
PMCPMC13326056

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.