ArticleScientific reports2026
Integration of transcriptome and DNA methylation reveals the mechanism of cilia-related genes in recurrent miscarriage.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Recurrent miscarriage (RM), a complex pregnancy disorder with largely undefined molecular mechanisms, has been associated with epigenetic abnormalities in chorionic tissue. This study aimed to elucidate methylation-dependent cilia-related genes (CRGs) implicated in RM. An integrative analysis combining RNA sequencing, public transcriptome data, and DNA methylation profiles was conducted to identify RM-related CRGs. Machine learning algorithms were applied to determine the most relevant candidates. Immune infiltration profiling, gene set enrichment analysis (GSEA), and competitive endogenous RNA (ceRNA) network construction were employed to clarify molecular pathways. RT-qPCR validation was performed using clinical samples. Fourteen methylation-regulated CRGs were identified, among which SLC1A2 and ZDHHC20 were confirmed as key candidates. GSEA indicated their association with spliceosome, cell cycle, and proteasome pathways. Immune analysis demonstrated decreased infiltration of activated CD4
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