Evidence mapPaperPMID 42106751Full record

ArticleBMC public health2026

Mortality trends and epidemiological characteristics among people living with HIV in Huangshi, China: a time-series analysis (2004-2024).

Qingzhi Wang, Haozhen Bai, Li Song, Can Wang, Youyi Xie, Biao Fu, Jumin Xie, Luman Li

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Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Qingzhi Wang *Medical College of YiChun University, Yichun, Jiangxi, 336000, P. R. China.
Haozhen Bai *Hubei Key Laboratory of Renal Disease Occurrence and Intervention, Medical School, Hubei Polytechnic University, Guilin North Road, No 16, Huangshi, Hubei, 435003, P. R. China.
Li Song *Hubei Key Laboratory of Renal Disease Occurrence and Intervention, Medical School, Hubei Polytechnic University, Guilin North Road, No 16, Huangshi, Hubei, 435003, P. R. China.
Can WangHubei Key Laboratory of Renal Disease Occurrence and Intervention, Medical School, Hubei Polytechnic University, Guilin North Road, No 16, Huangshi, Hubei, 435003, P. R. China.
Youyi XieHubei Key Laboratory of Renal Disease Occurrence and Intervention, Medical School, Hubei Polytechnic University, Guilin North Road, No 16, Huangshi, Hubei, 435003, P. R. China.
Biao FuHuangshi Central Hospital, Huangshi Public Health Medical Treatment Center, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei, 435000, P. R. China.
Jumin XieHubei Key Laboratory of Renal Disease Occurrence and Intervention, Medical School, Hubei Polytechnic University, Guilin North Road, No 16, Huangshi, Hubei, 435003, P. R. China. xiejm922@163.com.ORCID 0000-0002-4493-4548
Luman LiDepartment of Obstetrics, Zhongnan Hospital of Wuhan University, Donghu Road No 169, Wuchang District, Wuhan, Hubei, 430071, P. R. China. lumanli@whu.edu.cn.

Funding

Key Project in the Scientific Research Plan of the Hubei Province Education Department D20234505Open Fund Project of Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention 2024SJ104Open fund research project of Huangshi Key Laboratory of Molecular Diagnosis and Individualized Therapy FZ2024005
6 · The paper itself

Abstract

objectiveTo analyze the epidemiological characteristics and dynamic trends of people living with HIV (PLWH) in Huangshi between 2004 and 2024, thereby providing a scientific basis for the optimization of regional HIV prevention and control strategies.

methodsSurveillance data of PLWH from Huangshi during the period 2004-2024 were collected. Descriptive epidemiology methods were employed to examine the temporal distribution, demographic features (including age, sex, marital status), transmission routes, clinical manifestations, and mortality patterns. A Cochrane-Armitage trend test was utilized to assess changes in gender composition, while SPSS 27 was leveraged to establish a time-series model based on exponential smoothing techniques to forecast future mortality counts.

resultsThe number of PLWH in Huangshi exhibited a marked increase post-2009, peaking in 2015, followed by a significant decline from 2020 onward. Key structural shifts were observed: (1) among reported cases, the 51-80 age group accounted for the highest proportion (representing the age composition within the infected population, rather than age-specific incidence in the general population). Male cases showed a pronounced upward trend, whereas female cases demonstrated a gradual decrease. (2) Sexual transmission constituted the predominant mode, accounting for 95.02% of cases, with heterosexual transmission highly concentrated among males aged 51-70 years. (3) The primary opportunistic infections were persistent fever and Pneumocystis pneumonia. Post-2013, mortality rates escalated significantly, yet over one-third of deaths were attributed to causes unrelated to HIV, with cardiovascular diseases and malignancies ranking as major contributors, reflecting a shift toward chronic comorbidity management. (4) Time-series modeling predicted a gradual decline in the estimated number of HIV-related deaths for the years 2025-2028.

conclusionHIV transmission in Huangshi has evolved into a stage characterized by sexual transmission as the primary route, with a notable increase in the disease burden among older adults and males. The focus is now transitioning from HIV-related mortality to the management of chronic comorbidities. Future HIV prevention efforts in the city should adopt comprehensive strategies, including targeted interventions and enhanced surveillance for males-particularly older males-strengthened treatment and prevention measures, and integrated approaches to chronic disease management to address the evolving epidemiological landscape.

Indexed as

HIV InfectionsMortalityAdolescentAdultAgedAged, 80 and overChildChild, PreschoolChinaFemaleHumansMaleMiddle AgedYoung AdultAIDSEpidemiological characteristicsHuangshiMortalityTime-series modeling

Identifiers

PMID42106751
PMCPMC13326291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.