Evidence map›Paper›PMID 42107639›Full record

ArticleThe Journal of biological chemistry2026

Lipid transfer proteins and PI4KIIα initiate nuclear p53-phosphoinositide signaling.

Noah D Carrillo, Mo Chen, Poorwa Awasthi, Tianmu Wen, Xue Yang, Colin Sterling, Dhruv Brahmbhatt, Vincent L Cryns, Richard A Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Noah D CarrilloUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Mo ChenUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Poorwa AwasthiUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Tianmu WenUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Xue YangUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Colin SterlingUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Dhruv BrahmbhattUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Vincent L CrynsUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA; Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: vlcryns@medicine.wisc.edu.
Richard A AndersonUniversity of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: raanders@wisc.edu.

Funding

Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Phosphoinositide Signaling in the Cytosol and NucleusR35GM134955 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson · 2020 to 2026
$5.0M
Regulation of Nuclear Akt by p53, MDM2 and Phosphoinositide Lipids Roles in Oncogenic Transformation and Tumor ProgressionR01CA286492 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Richard A. Anderson, VINCENT L. CRYNS · 2024 to 2026
$2.8M
NCI NIH HHS R01 CA286492NIEHS NIH HHS T32 ES007015NIGMS NIH HHS R35 GM134955
6 · The paper itself

Abstract

Phosphoinositide (PIP

Indexed as

Cell NucleusPhosphatidylinositolsPhospholipid Transfer ProteinsPhosphotransferases (Alcohol Group Acceptor)Signal TransductionTumor Suppressor Protein p53AnimalsHumansMinor Histocompatibility AntigensMinor Histocompatibility Antigensphosphatidylinositol phosphate 4-kinasePhosphatidylinositolsPhospholipid Transfer ProteinsPhosphotransferases (Alcohol Group Acceptor)Tumor Suppressor Protein p53Aktcell stresslinked PIPsnucleusp53phosphoinositidePI3,4,5P(3)PI4,5P(2)PI4KIIαPITP

Identifiers

PMID42107639
PMCPMC13260207

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.