Evidence map›Paper›PMID 42107643›Full record

ArticleThe Journal of biological chemistry2026

Structural basis for inhibition of the voltage-gated sodium channel Na

Hang Wu, Wenxing Wang, Zhaotun Hu, Yekui Yin, Dezheng Peng, Qing Zhou, Xi He, Bo Zhu, Guyu Zhong, Jie Zhong and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hang WuThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Wenxing WangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Zhaotun HuKey Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, College of Biological and Food Engineering, Huaihua University, Huaihua, China.
Yekui YinThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Dezheng PengThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Qing ZhouThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Xi HeThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Bo ZhuSchool of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan.
Guyu ZhongSchool of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan.
Jie ZhongResearch Department, Hunan Provincial People's Hospital and The First Afffliated Hospital of Hunan Normal University, Changsha, Hunan, China.
Xinlong HaoSchool of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan.
Yin WangThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Zhonghua LiuThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China.
Minzhi ChenThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China. Electronic address: chenmz@hunnu.edu.cn.
Jia WangDepartment of Respiratory and Critical Care Medicine, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China. Electronic address: wangjia@hunnu.edu.cn.
Yunxiao ZhangSchool of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan. Electronic address: zhangyx@hnist.edu.cn.
Xi ZhouThe National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Institute of Interdisciplinary Studies, Peptide and Small Molecule Drug R&D Platform, Furong Laboratory, Hunan Normal University, Changsha, China. Electronic address: xizh@hunnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The voltage-gated sodium channel Na

Indexed as

NAV1.7 Voltage-Gated Sodium ChannelPeptidesSpider VenomsVoltage-Gated Sodium Channel BlockersAnimalsHumansMutagenesis, Site-DirectedSpidersNAV1.7 Voltage-Gated Sodium ChannelPeptidesSCN9A protein, humanSpider VenomsVoltage-Gated Sodium Channel BlockersHWTX-INa(V)1.7painspider venom-derived peptide toxinstoxin-channel interactionvoltage-gated sodium channel

Identifiers

PMID42107643
PMCPMC13266018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.