Observational studyEBioMedicine2026
Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection.
Observational study in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
Funding
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Abstract
backgroundOrthoflaviviruses, as exemplified by the prototypic yellow fever virus (YFV), have been recently identified by the World Health Organisation as major pandemic threats. Although factors such as globalisation and climate change have been identified to increase the prevalence of orthoflaviviral diseases, the ongoing obesity pandemic is a neglected but important contributory factor to exacerbating the risk of severe orthoflaviviral diseases. Indeed, how obesity affects the outcome of orthoflaviviral infection remains undefined.
methodsWe used the live attenuated yellow fever vaccine (YF17D-204 strain and hereon referred to as YF17D) to simulate an acute orthoflaviviral infection. We enrolled, using the WHO Asian-BMI classification, 34 participants without obesity (18 kg/m
findingsWe found increased prevalence of systemic symptoms; myalgia and axillary soreness from lymphadenopathy were more common in participants with obesity compared to those without despite comparable YF17D RNAaemia levels. Moreover, transcriptomic and cytokine profiling revealed BMI-dependent differences in pro-inflammatory states at both pre- and post-infection.
interpretationOur findings indicate obesity as a susceptibility factor of symptomatic orthoflaviviral infection and suggest anti-inflammatory approaches to mitigate risks of severe orthoflaviviral diseases.
fundingNational Medical Research Council of Singapore.
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