Evidence map›Paper›PMID 42108366›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

EGCG-mediated selenium nanoparticles protect against 5-fluorouracil-induced cardiotoxicity via Nrf2/Keap1 signaling.

Khaled M Alam-ElDein, Moustafa Mahmoud Abdelaziz, Salma Sabry Elgezery, Youssef Tarek Fouad, Miriam Amir Mousa, Ahmed M Elmosilhi, Malak Mostafa Mohamed, Salma A Abdo, Mennatallah T Ali, Basmala Shaher Mohamed and 4 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Khaled M Alam-ElDeinMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Moustafa Mahmoud AbdelazizMolecular Biology and Biotechnology Department, School of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Salma Sabry ElgezerySchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Youssef Tarek FouadSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Miriam Amir MousaSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Ahmed M ElmosilhiSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Malak Mostafa MohamedSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Salma A AbdoSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Mennatallah T AliSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Basmala Shaher MohamedSchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Radwa A HanafySchool of Biotechnology, Badr University in Cairo, Badr City, Cairo, 11829, Egypt.
Alzahraa A ElhemielyDepartment of Pharmacology, Egyptian Drug Authority (EDA)-Formerly NODCAR, Giza, 12654, Egypt.
Mohamed H A GadelmawlaLife Sciences Department, Faculty of Biotechnology, Sinai University, Kantara Branch, Ismailia, 41636, Egypt. mohamed.hassany@su.edu.eg.
Nievin Ahmed MahranDepartment of Biochemistry, Faculty of Biotechnology, Kantara Branch, Sinai University, Ismailia, 41636, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Fluorouracil (5-FU) is a widely used anticancer drug; however, its clinical application is limited by severe adverse effects, particularly cardiotoxicity. This study investigated the cardioprotective potential of epigallocatechin gallat-mediated selenium nanoparticles (EGCG-SeNPs) against 5-FU-induced cardiac injury in rats and explored the underlying mechanisms, with a specific focus on comparing the efficacy of the combined therapy versus EGCG or selenium monotherapy. In silico molecular docking was performed to evaluate the interaction of EGCG with inducible nitric oxide synthase (iNOS), glutathione S-transferase (GST), and tumor necrosis factor-α (TNF-α). Thirty-five male Wistar rats were randomly assigned to five groups: control, 5-FU, Na

Indexed as

Antimetabolites, AntineoplasticCatechinFluorouracilHeart DiseasesKelch-Like ECH-Associated Protein 1NanoparticlesNF-E2-Related Factor 2SeleniumAnimalsAntioxidantsApoptosisCardiotoxicityMaleOxidative StressRatsRats, WistarAntimetabolites, AntineoplasticAntioxidantsCatechinepigallocatechin gallateFluorouracilKEAP1 protein, ratKelch-Like ECH-Associated Protein 1Nfe2l2 protein, ratNF-E2-Related Factor 2Selenium5-FluorouracilCardio-oncologyCardiotoxicityEpigallocatechin gallateFluoropyrimidine toxicityNrf2/Keap1 signalingRedox signalingSelenium nanoparticles

Identifiers

PMID42108366

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.