Evidence map›Paper›PMID 42108367›Full record

ReviewNeuroscience bulletin2026

Disruptions in RNA Splicing: A Key Regulator of Cognitive Impairment in Perioperative Neurocognitive Disorders.

Xu-An Wang, Qing-Ya Wu, Xiao-Yu Shi, Xiao-Peng Wang, Yan-Yan Gao, Wei-Wei Zhang, Yi-Sheng Lu, Dan Liu, Ling-Qiang Zhu, Hua Zheng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xu-An Wang *Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Qing-Ya Wu *Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xiao-Yu Shi *Department of Conservative Dentistry and Endodontics, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.
Xiao-Peng WangDepartment of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Yan-Yan GaoDepartment of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Wei-Wei ZhangDepartment of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Yi-Sheng LuDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Dan LiuDepartment of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Ling-Qiang ZhuDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. zhulq@mail.hust.edu.cn.ORCID http://orcid.org/0000-0001-9964-9229
Hua ZhengDepartment of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. hzheng@hust.edu.cn.ORCID http://orcid.org/0000-0003-0134-0990

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perioperative neurocognitive disorders (PND) encompass a spectrum of cognitive impairments that emerge during the perioperative period. The pathogenesis of PND is multifactorial, involving complex interactions between neuroinflammation, impairment of synaptic plasticity, dysregulation of brain-derived neurotrophic factor (BDNF) signaling, oxidative stress, and mitochondrial dysfunction. RNA splicing is increasingly recognized as a critical player in nervous system function and dysfunction. In this review, we explore the role of RNA splicing in modulating the major pathogenic mechanisms of PND. We highlight how aberrant splicing events promote neuroinflammation by altering the expression of pro-inflammatory genes, disrupt synaptic plasticity by modifying the profiles of synaptic proteins and neurotransmitter receptors, and impair the expression and function of BDNF. Additionally, RNA splicing abnormalities exacerbate oxidative stress and mitochondrial dysfunction, further amplifying neuronal damage. By elucidating the intricate interactions between RNA splicing and these core pathological processes, this review reveals the close association between RNA splicing dysregulation and the molecular underpinnings of PND, and highlights its potential regulatory role in PND pathogenesis.

Indexed as

Cognitive DysfunctionNeurocognitive DisordersRNA SplicingAnimalsBrain-Derived Neurotrophic FactorHumansNeuroinflammatory DiseasesNeuronal PlasticityOxidative StressPerioperative PeriodBrain-Derived Neurotrophic FactorBDNFMitochondrial dysfunctionNeuroinflammationOxidative stressPerioperative neurocognitive disordersRNA splicingSynaptic plasticity

Identifiers

PMID42108367
PMCPMC13424044

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.