Evidence map›Paper›PMID 42108398›Full record

ArticleMagnetic resonance in medicine2026

Hemodynamic Modeling and Phase-Adjustable Reconstruction of Hyperpolarized Cardiac

Sung-Han Lin, Corey Mozingo, Crystal E Harrison, Kelley A Derner, Craig R Malloy, Jae Mo Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sung-Han LinAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0003-1384-4037
Corey MozingoAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA.
Crystal E HarrisonAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA.
Kelley A DernerAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA.
Craig R MalloyAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0001-5077-0642
Jae Mo ParkAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-7404-6971

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Development of early metabolic imaging biomarkers for muscular dystrophy and cardiomyopathy in patientsR01HL170039 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PRADEEP P.A. MAMMEN, Jae Mo Park · 2024 to 2026
$2.2M
A Clinical MR Scanner for Imaging Hyperpolarized Carbon-13S10RR029119 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2011 to 2011
$2.2M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
Muscular Dystrophy Association MDA963281NCRR NIH HHS S10RR029119NHLBI NIH HHS R01HL170039NIBIB NIH HHS P41EB015908NIH Office of the Director S10OD018468
6 · The paper itself

Abstract

purposeTo deconvolve cardiac phase and hemodynamic effects in hyperpolarized (HP) [1-

methodsCardiac phase drift during dynamic acquisition of HP

resultsPhantom simulations demonstrated that heart rate variability induces cardiac phase misalignment, causing substantial distortion of dynamic HP pyruvate timecourses. Human studies showed transient heart rate changes during pyruvate bolus arrival, resulting in phase shifts. Multiphase

conclusionWe present a volume-guided hemodynamic modeling and reconstruction framework that corrects cardiac phase misalignment. This approach improves quantitative robustness across varying heart rates and is applicable to both ECG-gated and nongated acquisitions.

Indexed as

ElectrocardiographyHeartHemodynamicsImage Processing, Computer-AssistedMagnetic Resonance Imaging, CineAdultAlgorithmsCarbon IsotopesComputer SimulationFemaleHeart RateHumansMagnetic Resonance SpectroscopyMaleModels, CardiovascularPhantoms, ImagingCarbon IsotopesPyruvic Acidcardiac metabolismhemodyanmicshuman hearthyperpolarized pyruvatekinetic modeling

Identifiers

PMID42108398
PMCPMC13327463

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.