Mitochondrial Localization and Abundance of Leishmania Cytochrome c Oxidase Subunit IV Is Maintained Following Loss of Mitochondrial Membrane Potential Associated With Mammalian Temperature.

Isabel Stephany-Brassesco, Edward J Wojcik, Justin C Smith, Ben L Kelly

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Article in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Isabel Stephany-BrassescoDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Edward J WojcikDepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Justin C SmithDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Ben L KellyDepartment of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Funding

Louisiana Board of Regents LEQSF(2023-26)-RD-A-17NSF 2341385

6 · The paper itself

Abstract

In eukaryotes, exposure to elevated temperature can disrupt cellular activities, including mitochondrial membrane potential (ΔΨm). Among multiple impacts, loss of ΔΨm typically results in mislocalization of nuclear-encoded mitochondria-destined proteins followed by their proteostatic degradation. As part of their natural transmission cycle, Leishmania encounter an abrupt temperature increase when inoculated into mammalian hosts via the bite of phlebotomine sandflies. How Leishmania maintain mitochondrial protein import in the face of this heat stress remains unknown. We therefore examined the relationship between ΔΨm, abundance of L. major cytochrome c oxidase complex subunit IV (LmCOX4) and its cellular localization functions at insect and mammalian temperatures. Intriguingly, LmCOX4 contains both a mitochondrial targeting sequence (MTS

Indexed as

Electron Transport Complex IVLeishmania majorMembrane Potential, MitochondrialMitochondriaAnimalsHot TemperatureProtein TransportProtozoan ProteinsTemperatureElectron Transport Complex IVProtozoan Proteinscytochrome c oxidaseimportLeishmanialife cyclemitochondrionprotein abundance

Identifiers

PMID42109019

DOI10.1111/mmi.70077

PMCPMC13353587

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