Evidence map›Paper›PMID 42109507›Full record

ArticleFrontiers in bioinformatics2026

Public health risk stratification using hybrid machine learning: a reproducible analysis of performance, stability, and risk attribution.

Alejandro Cabrera-Andrade, Ana Karina Zambrano, Joselin García-Ortiz, William Villegas-Ch

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alejandro Cabrera-AndradeCarrera de Enfermería, Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, Ecuador.
Ana Karina ZambranoCentro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador.
Joselin García-OrtizEscuela de Ingeniería en Ciberseguridad, Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Américas, Quito, Ecuador.
William Villegas-ChEscuela de Ingeniería en Ciberseguridad, Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Américas, Quito, Ecuador.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Risk stratification in public health involves organizing heterogeneous health-related signals into consistent representations that support population-level analysis. In large-scale datasets, such as National Health and Nutrition Examination Survey (NHANES) and Behavioral Risk Factor Surveillance System (BRFSS), the integration of clinical, biometric, behavioral, and self-reported variables introduces structural variability that challenges conventional modeling approaches. This study proposes a hybrid learning framework that combines linear and nonlinear components to analyze induced risk representations derived from multidimensional health data. The model is evaluated using NHANES 2017-2018, BRFSS 2019, and an Integrated Public Health Dataset constructed through semantic harmonization of both sources. The experimental design is based on a controlled formulation in which a continuous risk index is constructed from the available variables and discretized into ordinal classes using quantiles, enabling systematic analysis of how models approximate structured partitions of the input space rather than predicting independent clinical outcomes. The results show that the hybrid scheme maintains consistent macro F1 and macro-ROC-AUC values across all scenarios with low fold-to-fold variability, reflecting the regularity of the induced class structure rather than predictive generalization. Attribution analysis reveals that the organization of the risk representation varies according to the nature of the data, with concentrated patterns in clinical signals, distributed contributions in behavioral variables, and intermediate structures in the integrated dataset. These findings demonstrate that hybrid schemes provide a stable and interpretable framework for analyzing the structural organization of risk in heterogeneous public health data.

Indexed as

artificial intelligenceexplainable risk attributionhybrid machine learningpublic health data integrationrisk stratification

Identifiers

PMID42109507
PMCPMC13149263

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.