Evidence map›Paper›PMID 42109849›Full record

ArticleiScience2026

Cold induced pain elicits reproducible breath metabolomic responses across geographically distinct populations.

Mélina Richard, Kapil Dev Singh, Dilan Sezer, Sarah Buergler, Luana Palermo, Yannick Schulz, Zhifeng Tang, Xin Luo, Urs Frey, Philippe C Cattin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mélina RichardUniversity Children's Hospital Basel (UKBB), Spitalstrasse 33, 4031 Basel, Switzerland.
Kapil Dev SinghUniversity Children's Hospital Basel (UKBB), Spitalstrasse 33, 4031 Basel, Switzerland.
Dilan SezerFaculty of Psychology, University of Basel, Missionsstrasse 60/62, 4055 Basel, Switzerland.
Sarah BuerglerFaculty of Psychology, University of Basel, Missionsstrasse 60/62, 4055 Basel, Switzerland.
Luana PalermoUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Yannick SchulzFaculty of Psychology, University of Basel, Missionsstrasse 60/62, 4055 Basel, Switzerland.
Zhifeng TangCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.
Xin LuoCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.
Urs FreyUniversity Children's Hospital Basel (UKBB), Spitalstrasse 33, 4031 Basel, Switzerland.
Philippe C CattinDepartment of Biomedical Engineering, University of Basel, Hegenheimermattweg 167b, 4123 Allschwil, Switzerland.
Xue LiCollege of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Key Laboratory of Speed Capability Research, Jinan University, Guangzhou 510632, China.
Jens GaabFaculty of Psychology, University of Basel, Missionsstrasse 60/62, 4055 Basel, Switzerland.
Pablo SinuesUniversity Children's Hospital Basel (UKBB), Spitalstrasse 33, 4031 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Observer-independent assessment of nociceptive states is particularly important in non-communicative or vulnerable patient populations, where self-report is unavailable. In this proof-of-concept study, we explored whether exhaled breath metabolomics, measured in real time using secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS), can capture rapid physiological responses to the cold pressor test (CPT), a standardized model of acute sympathetic and nociceptive activation. Forty healthy adults (

Indexed as

clinical neurosciencehuman physiologymachine learningmetabolomicsomicssystems biology

Identifiers

PMID42109849
PMCPMC13156685

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.