Evidence map›Paper›PMID 42110218›Full record

ArticleObservational studies2025

Analytic Considerations for the Evaluation of Tuberculosis Preventative Therapy Effectiveness Among People Living with HIV.

Lindsey M Schader, Seth Zissette, Fadimatu Mishara, Macarthur Charles, Sarita Shah, David Benkeser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Observational studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lindsey M SchaderBiostatistics and Bioinformatics Emory University.
Seth ZissetteEpidemiology Emory University.
Fadimatu MisharaCDC Foundation.
Macarthur CharlesGlobal Tuberculosis Branch, Division of Global HIV and Tuberculosis, Center for Global Health Centers for Disease Control and Prevention.
Sarita ShahEpidemiology Emory University.
David BenkeserBiostatistics and Bioinformatics Emory University.

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
NIAID NIH HHS P30 AI168386
6 · The paper itself

Abstract

Despite data from randomized trials demonstrating the benefits of tuberculosis preventive treatment (TPT) for people living with HIV, there remain gaps in the large-scale programmatic provision of TPT and understanding of its impact. The PROTECT study is a multi-country study that aims to evaluate the effectiveness of TPT programs on tuberculosis incidence and mortality. The study leverages electronic health records, which poses challenges in the design, analysis, and interpretation of the data. In this work, we describe the general analysis approach that will be adopted across countries for evaluation of the effectiveness of TPT programs.

Indexed as

causal inferenceelectronic health recordsmarginal structural modelsobservational studytarget trial emulation

Identifiers

PMID42110218
PMCPMC13155345

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.