ArticleFrontiers in bioengineering and biotechnology2026
Synergistic antibacterial and osteogenic activities of GO/GelMA hydrogel for regenerating periodontal bone defects.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to develop and assess graphene oxide (GO) and methacrylated gelatin (GelMA) composite hydrogels (GO/GelMA) for their combined antibacterial and osteogenic properties in the treatment of periodontitis-induced bone defects through comprehensive Methods: GO was synthesized via a modified Hummers method and incorporated into GelMA to form composite hydrogels. The physical properties, including porosity, swelling behavior, and mechanical strength, were characterized. Antibacterial activity was evaluated against Results: The GO/GelMA hydrogels exhibited favorable physicochemical properties for bone tissue engineering. The incorporation of GO significantly enhanced the antibacterial performance, effectively inhibiting the Conclusion: The GO/GelMA hydrogels, particularly at a GO concentration of 200 µg/mL, demonstrate excellent synergistic antibacterial and osteogenic properties, holding great promise for treating periodontitis-related bone defects.
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