ReviewFrontiers in bioengineering and biotechnology2026
Bifunctional scaffolds: strategic bridges coordinating osteosarcoma therapy and bone regeneration.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Theragenerative Nanomaterials: Integrating Therapy, Regeneration, and Diagnosis-Navigating the Shared Pathways Between Tissue Repair and Malignancy.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma (OS), recognized as the most common primary malignant bone tumor, presents substantial clinical challenges. The current standard of care, involving extensive surgical resection followed by adjuvant chemotherapy, often leads to critical-size bone defects and is hampered by high risks of local recurrence, metastasis and systemic toxicity. Conventional bone scaffolds are constrained by their purely mechanical role, lacking the inherent bioactivity required for a therapeutic function within the regenerative microenvironment. This significant and unresolved clinical challenge has driven the advancement of sophisticated biomaterial platforms aimed at achieving the dual objectives of effective osteosarcoma elimination and concurrent bone tissue regeneration. This review comprehensively explores the design principles of these scaffolds, detailing their use as a structural base and the integration of key components for antineoplastic strategies and osteogenesis. Furthermore, it delves into advanced smart material systems, including stimuli-responsive drug release platforms and 3D printing technologies for creating patient-specific implants. The discussion also encompasses the critical
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.