Evidence map›Paper›PMID 42110406›Full record

ArticleFrontiers in medicine2026

Identification of novel tumor protein 63 variant associated with split-hand/foot malformation and tooth agenesis.

Jie-Yi Long, Qin-Zhi Liu, Si-Hua Chang, Run-Yan Wang, Jie-Yuan Jin, Ning Li, Zhen-Bo Cheng

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie-Yi Long *Department of Hand and Microsurgery, Xiangya Hospital, School of Life Sciences, Central South University, Changsha, China.
Qin-Zhi Liu *Department of Hand and Microsurgery, Xiangya Hospital, School of Life Sciences, Central South University, Changsha, China.
Si-Hua ChangDepartment of Hand and Microsurgery, Xiangya Hospital, School of Life Sciences, Central South University, Changsha, China.
Run-Yan WangDepartment of Hand and Microsurgery, Xiangya Hospital, School of Life Sciences, Central South University, Changsha, China.
Jie-Yuan JinDepartment of Hand and Microsurgery, Xiangya Hospital, School of Life Sciences, Central South University, Changsha, China.
Ning LiPhysical Education Institute, Hunan University of Financial and Economic, Changsha, China.
Zhen-Bo ChengDepartment of Clinical Laboratory, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Hunan Normal University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Split-hand/foot malformation (SHFM) is a serious congenital anomaly. A multitude of pathogenic genes associated with SHFM have been identified; Methods: We identified a pathogenic variant by extracting DNA from the peripheral blood of a patient with SHFM and performing whole-exome sequencing (WES). After verifying the variant through Sanger sequencing, a series of analytical procedures were conducted to determine its pathogenicity. These included conservative analysis, tolerance analysis of the mutant region, and three-dimensional molecular modeling of the protein. Results: A Conclusion: We identified a

Indexed as

congenital limb deformitySHFMtooth agenesisTP63whole exome sequencing

Identifiers

PMID42110406
PMCPMC13152756

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.